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Does oestradiol attenuate the damaging effects of a fructose-rich diet on cardiac Akt/endothelial nitric oxide synthase signalling?

Overview of attention for article published in British Journal of Nutrition, October 2012
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Title
Does oestradiol attenuate the damaging effects of a fructose-rich diet on cardiac Akt/endothelial nitric oxide synthase signalling?
Published in
British Journal of Nutrition, October 2012
DOI 10.1017/s0007114512004114
Pubmed ID
Authors

Snjezana Romic, Snezana Tepavcevic, Zorica Zakula, Tijana Milosavljevic, Mojca Stojiljkovic, Maja Zivkovic, Milan Popovic, Aleksandra Stankovic, Goran Koricanac

Abstract

Fructose-rich diets (FRD) cause cardiac insulin resistance manifested by impairment of Akt/endothelial NO synthase (eNOS) signalling. In contrast, oestradiol (E2) activates this signalling pathway in the heart. To study the ability of E2 to revert the detrimental effect of fructose on cardiac Akt/eNOS, female rats were subjected to a FRD and ovariectomy followed with or without E2 replacement. We also analysed the effects of the FRD and E2 on cardiac extracellular signal-regulated kinase (Erk 1/2) signalling related to their role in cardiac hypertrophy development. Expression of Akt, eNOS and Erk 1/2, as well as regulatory phosphorylations of these molecules were determined. The protein expression of cardiac Akt and eNOS was not affected by the diet or E2 treatment. However, the FRD was accompanied by a decrease in Akt phosphorylation at Ser(473) and Thr(308), and eNOS at Ser(1177), while the phosphorylation of eNOS at Thr(495) was increased. E2 replacement in ovariectomised fructose-fed rats caused a reversion of the diet effect on Akt and eNOS serine phosphorylation, but mostly had no effect on threonine phosphorylation of the molecules. The FRD and E2 treatment did not influence Erk 1/2 expression and phosphorylation and heart mass as well. The data show that E2 selectively suppress the negative effects of a FRD on Akt/eNOS signalling and probably point to the different effects of E2 on kinase/phosphatase pathways responsible for phosphorylation/dephosphorylation of Akt and eNOS. Furthermore, the results suggest that the heart of females in the reproductive period is partially protected against the damaging effects of increasedfructose intake.

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Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 25%
Student > Master 2 13%
Professor > Associate Professor 2 13%
Student > Doctoral Student 1 6%
Other 1 6%
Other 2 13%
Unknown 4 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 25%
Medicine and Dentistry 3 19%
Nursing and Health Professions 2 13%
Agricultural and Biological Sciences 1 6%
Psychology 1 6%
Other 2 13%
Unknown 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2013.
All research outputs
#11,031,563
of 12,412,180 outputs
Outputs from British Journal of Nutrition
#4,115
of 4,488 outputs
Outputs of similar age
#122,418
of 146,159 outputs
Outputs of similar age from British Journal of Nutrition
#49
of 56 outputs
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