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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structure of a CLC chloride ion channel by cryo-electron microscopy
|
|---|---|
| Published in |
Nature, December 2016
|
| DOI | 10.1038/nature20812 |
| Pubmed ID | |
| Authors |
Eunyong Park, Ernest B. Campbell, Roderick MacKinnon |
| Abstract |
CLC proteins transport chloride (Cl(-)) ions across cellular membranes to regulate muscle excitability, electrolyte movement across epithelia, and acidification of intracellular organelles. Some CLC proteins are channels that conduct Cl(-) ions passively, whereas others are secondary active transporters that exchange two Cl(-) ions for one H(+). The structural basis underlying these distinctive transport mechanisms is puzzling because CLC channels and transporters are expected to share the same architecture on the basis of sequence homology. Here we determined the structure of a bovine CLC channel (CLC-K) using cryo-electron microscopy. A conserved loop in the Cl(-) transport pathway shows a structure markedly different from that of CLC transporters. Consequently, the cytosolic constriction for Cl(-) passage is widened in CLC-K such that the kinetic barrier previously postulated for Cl(-)/H(+) transporter function would be reduced. Thus, reduction of a kinetic barrier in CLC channels enables fast flow of Cl(-) down its electrochemical gradient. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 25% |
| France | 1 | 6% |
| Canada | 1 | 6% |
| United Kingdom | 1 | 6% |
| Unknown | 9 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 56% |
| Scientists | 5 | 31% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Japan | 1 | <1% |
| Mexico | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 198 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 47 | 23% |
| Researcher | 25 | 12% |
| Student > Master | 20 | 10% |
| Student > Bachelor | 19 | 9% |
| Professor | 14 | 7% |
| Other | 42 | 21% |
| Unknown | 36 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 60 | 30% |
| Agricultural and Biological Sciences | 41 | 20% |
| Chemistry | 18 | 9% |
| Neuroscience | 8 | 4% |
| Medicine and Dentistry | 8 | 4% |
| Other | 26 | 13% |
| Unknown | 42 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2017.
All research outputs
#1,264,866
of 25,703,943 outputs
Outputs from Nature
#35,602
of 98,560 outputs
Outputs of similar age
#25,437
of 424,724 outputs
Outputs of similar age from Nature
#581
of 886 outputs
Altmetric has tracked 25,703,943 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,560 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.6. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,724 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 886 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.