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Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration

Overview of attention for article published in Cell & Bioscience, December 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#16 of 201)
  • Good Attention Score compared to outputs of the same age (77th percentile)

Mentioned by

news
1 news outlet

Citations

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21 Dimensions

Readers on

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74 Mendeley
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Title
Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration
Published in
Cell & Bioscience, December 2016
DOI 10.1186/s13578-016-0124-4
Pubmed ID
Authors

Onder Albayram, Megan K. Herbert, Asami Kondo, Cheng-Yu Tsai, Sean Baxley, Xiaolan Lian, Madison Hansen, Xiao Zhen Zhou, Kun Ping Lu

Abstract

One of the two common hallmark lesions of Alzheimer's disease (AD) brains is neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein (p-tau). NFTs are also a defining feature of other neurodegenerative disorders and have recently been identified in the brains of patients suffering from chronic traumatic encephalopathy (CTE). However, NFTs are not normally observed in traumatic brain injury (TBI) until months or years after injury. This raises the question of whether NFTs are a cause or a consequence of long-term neurodegeneration following TBI. Two conformations of phosphorylated tau, cis p-tau and trans p-tau, which are regulated by the peptidyl-prolyl isomerase Pin1, have been previously identified. By generating a polyclonal and monoclonal antibody (Ab) pair capable of distinguishing between cis and trans isoforms of p-tau (cis p-tau and trans p-tau, respectively), cis p-tau was identified as a precursor of tau pathology and an early driver of neurodegeneration in AD, TBI and CTE. Histological studies shows the appearance of robust cis p-tau in the early stages of human mild cognitive impairment (MCI), AD and CTE brains, as well as after sport- and military-related TBI. Notably, cis p-tau appears within hours after closed head injury and long before other known pathogenic p-tau conformations including oligomers, pre-fibrillary tangles and NFTs. Importantly, cis p-tau monoclonal antibody treatment not only eliminates cis p-tau induction and tau pathology, but also restores many neuropathological and functional outcome in TBI mouse models. Thus, cis p-tau is an early driver of tau pathology in TBI and CTE and detection of cis p-tau in human bodily fluids could potentially provide new diagnostic and prognostic tools. Furthermore, humanization of the cis p-tau antibody could ultimately be developed as a new treatment for AD, TBI and CTE.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 74 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 22%
Student > Ph. D. Student 12 16%
Researcher 11 15%
Student > Master 9 12%
Student > Doctoral Student 6 8%
Other 17 23%
Unknown 3 4%
Readers by discipline Count As %
Neuroscience 18 24%
Medicine and Dentistry 13 18%
Biochemistry, Genetics and Molecular Biology 12 16%
Agricultural and Biological Sciences 8 11%
Psychology 5 7%
Other 12 16%
Unknown 6 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2016.
All research outputs
#1,330,406
of 8,815,676 outputs
Outputs from Cell & Bioscience
#16
of 201 outputs
Outputs of similar age
#62,709
of 301,070 outputs
Outputs of similar age from Cell & Bioscience
#1
of 3 outputs
Altmetric has tracked 8,815,676 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 201 research outputs from this source. They receive a mean Attention Score of 2.2. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 301,070 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them