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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis
|
|---|---|
| Published in |
Cell, May 2013
|
| DOI | 10.1016/j.cell.2013.05.012 |
| Pubmed ID | |
| Authors |
Gal Haimovich, Daniel A. Medina, Sebastien Z. Causse, Manuel Garber, Gonzalo Millán-Zambrano, Oren Barkai, Sebastián Chávez, José E. Pérez-Ortín, Xavier Darzacq, Mordechai Choder |
| Abstract |
Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The balance between mRNA synthesis and decay determines these levels. We demonstrate that most yeast mRNAs are degraded by the cytoplasmic 5'-to-3' pathway (the "decaysome"), as proposed previously. Unexpectedly, the level of these mRNAs is highly robust to perturbations in this major pathway because defects in various decaysome components lead to transcription downregulation. Moreover, these components shuttle between the cytoplasm and the nucleus, in a manner dependent on proper mRNA degradation. In the nucleus, they associate with chromatin-preferentially ∼30 bp upstream of transcription start-sites-and directly stimulate transcription initiation and elongation. The nuclear role of the decaysome in transcription is linked to its cytoplasmic role in mRNA decay; linkage, in turn, seems to depend on proper shuttling of its components. The gene expression process is therefore circular, whereby the hitherto first and last stages are interconnected. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 29% |
| France | 1 | 7% |
| Guinea | 1 | 7% |
| United Kingdom | 1 | 7% |
| Spain | 1 | 7% |
| Unknown | 6 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 7 | 50% |
| Members of the public | 6 | 43% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 596 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 3% |
| United Kingdom | 4 | <1% |
| Germany | 3 | <1% |
| Russia | 2 | <1% |
| Portugal | 2 | <1% |
| France | 2 | <1% |
| Korea, Republic of | 1 | <1% |
| Turkey | 1 | <1% |
| Chile | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 562 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 182 | 31% |
| Researcher | 118 | 20% |
| Student > Master | 63 | 11% |
| Student > Bachelor | 46 | 8% |
| Professor > Associate Professor | 32 | 5% |
| Other | 93 | 16% |
| Unknown | 62 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 274 | 46% |
| Biochemistry, Genetics and Molecular Biology | 188 | 32% |
| Medicine and Dentistry | 16 | 3% |
| Computer Science | 9 | 2% |
| Immunology and Microbiology | 8 | 1% |
| Other | 34 | 6% |
| Unknown | 67 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2023.
All research outputs
#1,023,234
of 25,374,917 outputs
Outputs from Cell
#3,847
of 17,168 outputs
Outputs of similar age
#7,619
of 204,329 outputs
Outputs of similar age from Cell
#29
of 127 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,168 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.1. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 204,329 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.