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Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis

Overview of attention for article published in Cell, May 2013
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Citations

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182 Dimensions

Readers on

mendeley
473 Mendeley
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3 CiteULike
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Title
Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis
Published in
Cell, May 2013
DOI 10.1016/j.cell.2013.05.012
Pubmed ID
Authors

Gal Haimovich, Daniel A. Medina, Sebastien Z. Causse, Manuel Garber, Gonzalo Millán-Zambrano, Oren Barkai, Sebastián Chávez, José E. Pérez-Ortín, Xavier Darzacq, Mordechai Choder

Abstract

Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The balance between mRNA synthesis and decay determines these levels. We demonstrate that most yeast mRNAs are degraded by the cytoplasmic 5'-to-3' pathway (the "decaysome"), as proposed previously. Unexpectedly, the level of these mRNAs is highly robust to perturbations in this major pathway because defects in various decaysome components lead to transcription downregulation. Moreover, these components shuttle between the cytoplasm and the nucleus, in a manner dependent on proper mRNA degradation. In the nucleus, they associate with chromatin-preferentially ∼30 bp upstream of transcription start-sites-and directly stimulate transcription initiation and elongation. The nuclear role of the decaysome in transcription is linked to its cytoplasmic role in mRNA decay; linkage, in turn, seems to depend on proper shuttling of its components. The gene expression process is therefore circular, whereby the hitherto first and last stages are interconnected.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 473 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 15 3%
United Kingdom 4 <1%
Germany 3 <1%
France 3 <1%
Russia 2 <1%
Portugal 2 <1%
Canada 1 <1%
Turkey 1 <1%
Korea, Republic of 1 <1%
Other 6 1%
Unknown 435 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 157 33%
Researcher 100 21%
Student > Master 47 10%
Student > Bachelor 39 8%
Professor > Associate Professor 29 6%
Other 101 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 265 56%
Biochemistry, Genetics and Molecular Biology 127 27%
Unspecified 31 7%
Medicine and Dentistry 15 3%
Computer Science 8 2%
Other 27 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2018.
All research outputs
#512,729
of 13,188,641 outputs
Outputs from Cell
#2,308
of 14,847 outputs
Outputs of similar age
#6,470
of 150,301 outputs
Outputs of similar age from Cell
#39
of 139 outputs
Altmetric has tracked 13,188,641 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,847 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.3. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 150,301 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.