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Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis

Overview of attention for article published in Cell, May 2013
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Citations

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206 Dimensions

Readers on

mendeley
509 Mendeley
citeulike
3 CiteULike
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Title
Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis
Published in
Cell, May 2013
DOI 10.1016/j.cell.2013.05.012
Pubmed ID
Authors

Gal Haimovich, Daniel A. Medina, Sebastien Z. Causse, Manuel Garber, Gonzalo Millán-Zambrano, Oren Barkai, Sebastián Chávez, José E. Pérez-Ortín, Xavier Darzacq, Mordechai Choder

Abstract

Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The balance between mRNA synthesis and decay determines these levels. We demonstrate that most yeast mRNAs are degraded by the cytoplasmic 5'-to-3' pathway (the "decaysome"), as proposed previously. Unexpectedly, the level of these mRNAs is highly robust to perturbations in this major pathway because defects in various decaysome components lead to transcription downregulation. Moreover, these components shuttle between the cytoplasm and the nucleus, in a manner dependent on proper mRNA degradation. In the nucleus, they associate with chromatin-preferentially ∼30 bp upstream of transcription start-sites-and directly stimulate transcription initiation and elongation. The nuclear role of the decaysome in transcription is linked to its cytoplasmic role in mRNA decay; linkage, in turn, seems to depend on proper shuttling of its components. The gene expression process is therefore circular, whereby the hitherto first and last stages are interconnected.

Twitter Demographics

The data shown below were collected from the profiles of 14 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 509 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 15 3%
United Kingdom 4 <1%
Germany 3 <1%
Portugal 2 <1%
France 2 <1%
Russia 2 <1%
Canada 1 <1%
Turkey 1 <1%
Chile 1 <1%
Other 5 <1%
Unknown 473 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 162 32%
Researcher 106 21%
Student > Master 49 10%
Student > Bachelor 45 9%
Professor > Associate Professor 30 6%
Other 86 17%
Unknown 31 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 267 52%
Biochemistry, Genetics and Molecular Biology 146 29%
Medicine and Dentistry 16 3%
Computer Science 10 2%
Engineering 6 1%
Other 30 6%
Unknown 34 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2020.
All research outputs
#636,320
of 15,096,379 outputs
Outputs from Cell
#2,702
of 15,036 outputs
Outputs of similar age
#6,980
of 156,649 outputs
Outputs of similar age from Cell
#38
of 130 outputs
Altmetric has tracked 15,096,379 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,036 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,649 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 130 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.