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The liver

Overview of attention for article published in Adipocyte, October 2014
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1 tweeter

Citations

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6 Dimensions

Readers on

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22 Mendeley
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Title
The liver
Published in
Adipocyte, October 2014
DOI 10.4161/adip.21448
Pubmed ID
Authors

Barbara C. Fam, Christos N. Joannides, Sofianos Andrikopoulos

Abstract

Liver fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by obesity and dietary fat intake. Whether FBPase functions only in glucose metabolism or has other metabolic roles is currently unclear. In our recently published study, we examined the importance of liver FBPase in body weight regulation by performing a series of comprehensive physiological and biochemical assessments of energy balance and specific intervention studies in our transgenic mouse line that overexpresses FBPase specifically in the liver. Compared with negative littermates, these FBPase transgenic mice weighed 10% less, had 50% less adiposity, ate 15% less food but did not have altered energy expenditure. Increased circulating leptin and cholecystokinin levels, elevated fatty acid oxidation and reduced appetite stimulating neuropeptides, neuropeptide Y (NPY) and agouti-related peptide (AGRP), underpinned this phenotype. Blocking the action of FBPase returned food intake and body weight to those of the negative littermates. Our study is the first to identify liver FBPase as a previously unknown regulator of appetite and adiposity. Importantly, this work recognizes the liver as an important organ in appetite and body weight regulation. This commentary will provide further insight and expand on this novel concept that the liver does in fact play an important role in adiposity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 27%
Student > Bachelor 4 18%
Student > Ph. D. Student 3 14%
Researcher 3 14%
Student > Doctoral Student 2 9%
Other 2 9%
Unknown 2 9%
Readers by discipline Count As %
Medicine and Dentistry 8 36%
Agricultural and Biological Sciences 6 27%
Sports and Recreations 2 9%
Biochemistry, Genetics and Molecular Biology 1 5%
Social Sciences 1 5%
Other 1 5%
Unknown 3 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2013.
All research outputs
#5,238,282
of 7,006,523 outputs
Outputs from Adipocyte
#57
of 90 outputs
Outputs of similar age
#75,787
of 117,724 outputs
Outputs of similar age from Adipocyte
#6
of 6 outputs
Altmetric has tracked 7,006,523 research outputs across all sources so far. This one is in the 14th percentile – i.e., 14% of other outputs scored the same or lower than it.
So far Altmetric has tracked 90 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 117,724 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.