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Twitter Demographics
Mendeley readers
Attention Score in Context
| Title |
AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells
|
|---|---|
| Published in |
Cancer Immunology Research, June 2023
|
| DOI | 10.1158/2326-6066.cir-22-0254 |
| Pubmed ID | |
| Authors |
R. Leo Sakemura, Mehrdad Hefazi, Michelle J. Cox, Elizabeth L. Siegler, Sutapa Sinha, Michael J. Hansen, Carli M. Stewart, Jennifer M. Feigin, Claudia Manriquez Roman, Kendall J. Schick, Ismail Can, Erin E. Tapper, Paulina Horvei, Mohamad M. Adada, Evandro D. Bezerra, Lionel Aurelien Kankeu Fonkoua, Michael W. Ruff, Cynthia L. Forsman, Wendy K. Nevala, Justin C. Boysen, Renee C. Tschumper, Cory L. Grand, Kameswara R. Kuchimanchi, Lars Mouritsen, Jason M. Foulks, Steven L. Warner, Timothy G. Call, Sameer A. Parikh, Wei Ding, Neil E. Kay, Saad S. Kenderian |
| Abstract |
The receptor tyrosine kinase AXL is a member of the TAM (Tyro3, AXL, and proto-oncogene tyrosine-protein kinase Mer) family and plays pleiotropic roles in cancer progression. AXL is expressed in immunosuppressive cells, which contributes to decreased efficacy of immunotherapy. Therefore, we hypothesized that AXL inhibition could serve as a strategy to overcome resistance to chimeric antigen receptor T (CART)-cell therapy. To test this, we determined the impact of AXL inhibition on CD19-targeted CART (CART19)-cell functions. Our results demonstrate that T cells and CART cells express high levels of AXL. Specifically, higher levels of AXL on activated Th2 CART cells and M2-polarized macrophages were observed. AXL inhibition with small molecules or via genetic disruption in T cells demonstrated selective inhibition of Th2 CART cells, Th2 cytokines, reversal of CART-cell inhibition, and promotion of CART-cell effector functions. AXL inhibition is a novel strategy to enhance CART-cell functions through two independent, but complementary, mechanisms: targeting Th2 cells and reversing myeloid-induced CART-cell inhibition through selective targeting of M2-polarized macrophages. |
Twitter Demographics
The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 40% |
| Spain | 1 | 7% |
| Japan | 1 | 7% |
| Unknown | 7 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 67% |
| Scientists | 3 | 20% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 1 | 50% |
| Unknown | 1 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 50% |
| Unknown | 1 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2023.
All research outputs
#3,602,951
of 24,449,189 outputs
Outputs from Cancer Immunology Research
#419
of 1,471 outputs
Outputs of similar age
#60,068
of 348,519 outputs
Outputs of similar age from Cancer Immunology Research
#10
of 28 outputs
Altmetric has tracked 24,449,189 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,471 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,519 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.