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The HIV-1 pandemic: does the selective sweep in chimpanzees mirror humankind’s future?

Overview of attention for article published in Retrovirology, May 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

news
1 news outlet
twitter
3 X users

Citations

dimensions_citation
40 Dimensions

Readers on

mendeley
58 Mendeley
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1 CiteULike
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Title
The HIV-1 pandemic: does the selective sweep in chimpanzees mirror humankind’s future?
Published in
Retrovirology, May 2013
DOI 10.1186/1742-4690-10-53
Pubmed ID
Authors

Natasja G de Groot, Ronald E Bontrop

Abstract

An HIV-1 infection progresses in most human individuals sooner or later into AIDS, a devastating disease that kills more than a million people worldwide on an annual basis. Nonetheless, certain HIV-1-infected persons appear to act as long-term non-progressors, and elite control is associated with the presence of particular MHC class I allotypes such as HLA-B*27 or -B*57. The HIV-1 pandemic in humans arose from the cross-species transmission of SIVcpz originating from chimpanzees. Chimpanzees, however, appear to be relatively resistant to developing AIDS after HIV-1/SIVcpz infection. Mounting evidence illustrates that, in the distant past, chimpanzees experienced a selective sweep resulting in a severe reduction of their MHC class I repertoire. This was most likely caused by an HIV-1/SIV-like retrovirus, suggesting that chimpanzees may have experienced long-lasting host-virus relationships with SIV-like viruses. Hence, if natural selection is allowed to follow its course, prospects for the human population may look grim, thus underscoring the desperate need for an effective vaccine.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 2%
Kenya 1 2%
Unknown 56 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 22%
Student > Master 10 17%
Student > Bachelor 10 17%
Student > Ph. D. Student 8 14%
Professor 2 3%
Other 6 10%
Unknown 9 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 45%
Biochemistry, Genetics and Molecular Biology 9 16%
Immunology and Microbiology 3 5%
Medicine and Dentistry 3 5%
Environmental Science 2 3%
Other 6 10%
Unknown 9 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2023.
All research outputs
#3,372,790
of 25,545,162 outputs
Outputs from Retrovirology
#141
of 1,274 outputs
Outputs of similar age
#27,981
of 208,316 outputs
Outputs of similar age from Retrovirology
#9
of 29 outputs
Altmetric has tracked 25,545,162 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,274 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,316 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.