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Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, December 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

news
1 news outlet
twitter
19 tweeters
peer_reviews
1 peer review site
facebook
2 Facebook pages

Citations

dimensions_citation
57 Dimensions

Readers on

mendeley
81 Mendeley
citeulike
1 CiteULike
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Title
Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes
Published in
Proceedings of the National Academy of Sciences of the United States of America, December 2016
DOI 10.1073/pnas.1612322114
Pubmed ID
Authors

Vicente Andreu-Fernández, Mónica Sancho, Ainhoa Genovés, Estefanía Lucendo, Franziska Todt, Joachim Lauterwasser, Kathrin Funk, Günther Jahreis, Enrique Pérez-Payá, Ismael Mingarro, Frank Edlich, Mar Orzáez

Abstract

The Bcl-2 (B-cell lymphoma 2) protein Bax (Bcl-2 associated X, apoptosis regulator) can commit cells to apoptosis via outer mitochondrial membrane permeabilization. Bax activity is controlled in healthy cells by prosurvival Bcl-2 proteins. C-terminal Bax transmembrane domain interactions were implicated recently in Bax pore formation. Here, we show that the isolated transmembrane domains of Bax, Bcl-xL (B-cell lymphoma-extra large), and Bcl-2 can mediate interactions between Bax and prosurvival proteins inside the membrane in the absence of apoptotic stimuli. Bcl-2 protein transmembrane domains specifically homooligomerize and heterooligomerize in bacterial and mitochondrial membranes. Their interactions participate in the regulation of Bcl-2 proteins, thus modulating apoptotic activity. Our results suggest that interactions between the transmembrane domains of Bax and antiapoptotic Bcl-2 proteins represent a previously unappreciated level of apoptosis regulation.

Twitter Demographics

The data shown below were collected from the profiles of 19 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 80 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 30%
Student > Bachelor 8 10%
Researcher 8 10%
Student > Master 8 10%
Student > Doctoral Student 4 5%
Other 9 11%
Unknown 20 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 27 33%
Agricultural and Biological Sciences 18 22%
Chemistry 5 6%
Medicine and Dentistry 4 5%
Immunology and Microbiology 2 2%
Other 3 4%
Unknown 22 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2021.
All research outputs
#1,233,674
of 20,168,911 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#18,144
of 93,885 outputs
Outputs of similar age
#33,386
of 411,225 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#404
of 895 outputs
Altmetric has tracked 20,168,911 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 93,885 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.9. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 411,225 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 895 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.