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Twitter Demographics
Mendeley readers
Attention Score in Context
| Title |
Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, December 2016
|
| DOI | 10.1073/pnas.1612322114 |
| Pubmed ID | |
| Authors |
Vicente Andreu-Fernández, Mónica Sancho, Ainhoa Genovés, Estefanía Lucendo, Franziska Todt, Joachim Lauterwasser, Kathrin Funk, Günther Jahreis, Enrique Pérez-Payá, Ismael Mingarro, Frank Edlich, Mar Orzáez |
| Abstract |
The Bcl-2 (B-cell lymphoma 2) protein Bax (Bcl-2 associated X, apoptosis regulator) can commit cells to apoptosis via outer mitochondrial membrane permeabilization. Bax activity is controlled in healthy cells by prosurvival Bcl-2 proteins. C-terminal Bax transmembrane domain interactions were implicated recently in Bax pore formation. Here, we show that the isolated transmembrane domains of Bax, Bcl-xL (B-cell lymphoma-extra large), and Bcl-2 can mediate interactions between Bax and prosurvival proteins inside the membrane in the absence of apoptotic stimuli. Bcl-2 protein transmembrane domains specifically homooligomerize and heterooligomerize in bacterial and mitochondrial membranes. Their interactions participate in the regulation of Bcl-2 proteins, thus modulating apoptotic activity. Our results suggest that interactions between the transmembrane domains of Bax and antiapoptotic Bcl-2 proteins represent a previously unappreciated level of apoptosis regulation. |
Twitter Demographics
The data shown below were collected from the profiles of 19 tweeters who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 9 | 47% |
| Venezuela, Bolivarian Republic of | 4 | 21% |
| United Kingdom | 1 | 5% |
| Ireland | 1 | 5% |
| Unknown | 4 | 21% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 79% |
| Scientists | 3 | 16% |
| Unknown | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 93 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 29% |
| Researcher | 9 | 10% |
| Student > Master | 9 | 10% |
| Student > Bachelor | 8 | 9% |
| Professor | 4 | 4% |
| Other | 8 | 9% |
| Unknown | 29 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 32 | 34% |
| Agricultural and Biological Sciences | 19 | 20% |
| Chemistry | 5 | 5% |
| Medicine and Dentistry | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 1 | 1% |
| Unknown | 30 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2021.
All research outputs
#1,448,650
of 22,925,760 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#20,075
of 98,534 outputs
Outputs of similar age
#32,457
of 420,925 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#401
of 896 outputs
Altmetric has tracked 22,925,760 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,534 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.0. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,925 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 896 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.