| Chapter title |
Depression in Autoimmune Diseases.
|
|---|---|
| Chapter number | 7 |
| Book title |
Inflammation-Associated Depression: Evidence, Mechanisms and Implications
|
| Published in |
Current topics in behavioral neurosciences, May 2016
|
| DOI | 10.1007/7854_2016_7 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-951151-1, 978-3-31-951152-8
|
| Authors |
Christopher R. Pryce, Adriano Fontana, Pryce, Christopher R., Fontana, Adriano |
| Editors |
Robert Dantzer, Lucile Capuron |
| Abstract |
Up to 50% of patients with autoimmune diseases show an impairment of health-related quality of life and exhibit depression-like symptoms. The immune system not only leads to inflammation in affected organs, but also mediates behavior abnormalities including fatigue and depression-like symptoms. This review focuses on the different pathways involved in the communication of the immune system with the neuronal network and the body's timing system. The latter is built up by a hierarchically organized expression of clock genes. As discussed here, the activation of the immune system interferes with high amplitude expression of clock genes, an effect which may play a pivotal role in depression-like behavior in autoimmune diseases. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 129 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 22 | 17% |
| Student > Master | 14 | 11% |
| Student > Ph. D. Student | 12 | 9% |
| Researcher | 9 | 7% |
| Student > Doctoral Student | 8 | 6% |
| Other | 20 | 16% |
| Unknown | 44 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 26% |
| Biochemistry, Genetics and Molecular Biology | 10 | 8% |
| Neuroscience | 7 | 5% |
| Agricultural and Biological Sciences | 7 | 5% |
| Nursing and Health Professions | 6 | 5% |
| Other | 15 | 12% |
| Unknown | 50 | 39% |