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Inflammation-Associated Depression: Evidence, Mechanisms and Implications

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Cover of 'Inflammation-Associated Depression: Evidence, Mechanisms and Implications'

Table of Contents

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    Book Overview
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    Chapter 2 Evidence for Inflammation-Associated Depression
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    Chapter 5 Suicidality and Activation of the Kynurenine Pathway of Tryptophan Metabolism.
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    Chapter 6 Role of the Kynurenine Metabolism Pathway in Inflammation-Induced Depression: Preclinical Approaches.
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    Chapter 7 Depression in Autoimmune Diseases.
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    Chapter 12 Role of Kynurenine Metabolism Pathway Activation in Major Depressive Disorders.
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    Chapter 13 The Role of Dopamine in Inflammation-Associated Depression: Mechanisms and Therapeutic Implications
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    Chapter 14 Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms.
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    Chapter 19 Are Non-steroidal Anti-Inflammatory Drugs Clinically Suitable for the Treatment of Symptoms in Depression-Associated Inflammation?
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    Chapter 23 Mechanisms of Inflammation-Associated Depression: Immune Influences on Tryptophan and Phenylalanine Metabolisms.
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    Chapter 25 Stress-Induced Microglia Activation and Monocyte Trafficking to the Brain Underlie the Development of Anxiety and Depression.
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    Chapter 26 The Promise and Limitations of Anti-Inflammatory Agents for the Treatment of Major Depressive Disorder
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    Chapter 28 Inflammation-Associated Co-morbidity Between Depression and Cardiovascular Disease
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    Chapter 30 Brain Structures Implicated in Inflammation-Associated Depression
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    Chapter 31 Does Diet Matter? The Use of Polyunsaturated Fatty Acids (PUFAs) and Other Dietary Supplements in Inflammation-Associated Depression.
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    Chapter 37 Immune-to-Brain Communication Pathways in Inflammation-Associated Sickness and Depression
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    Chapter 40 Inflammation Effects on Brain Glutamate in Depression: Mechanistic Considerations and Treatment Implications.
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    Chapter 43 Role of Neuro-Immunological Factors in the Pathophysiology of Mood Disorders: Implications for Novel Therapeutics for Treatment Resistant Depression.
Attention for Chapter 25: Stress-Induced Microglia Activation and Monocyte Trafficking to the Brain Underlie the Development of Anxiety and Depression.
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Chapter title
Stress-Induced Microglia Activation and Monocyte Trafficking to the Brain Underlie the Development of Anxiety and Depression.
Chapter number 25
Book title
Inflammation-Associated Depression: Evidence, Mechanisms and Implications
Published in
Current topics in behavioral neurosciences, June 2016
DOI 10.1007/7854_2016_25
Pubmed ID
Book ISBNs
978-3-31-951151-1, 978-3-31-951152-8
Authors

Karol Ramirez, Jaime Fornaguera-Trías, John F. Sheridan

Editors

Robert Dantzer, Lucile Capuron

Abstract

Psychosocial stress is capable of causing immune dysregulation and increased neuroinflammatory signaling by repeated activation of the neuroendocrine and autonomic systems that may contribute to the development of anxiety and depression. The stress model of repeated social defeat (RSD) recapitulates many of the stress-driven alterations in the neuroimmune system seen in humans experiencing repeated forms of stress and associated affective disorders. For example, RSD-induced neuronal and microglia activation corresponds with sympathetic outflow to the peripheral immune system and increased ability of bone marrow derived myeloid progenitor cells (MPC) to redistribute throughout the body, including to the central nervous system (CNS), reinforcing stress-associated behaviors. An overview of the neuroendocrine, immunological, and behavioral stress-induced responses will be reviewed in this chapter using RSD to illustrate the mechanisms leading to stress-related alterations in inflammation in both the periphery and CNS, and stress-related changes in behavioral responses.

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 68 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 33%
Student > Bachelor 7 10%
Student > Master 7 10%
Researcher 6 9%
Student > Doctoral Student 5 7%
Other 10 14%
Unknown 11 16%
Readers by discipline Count As %
Medicine and Dentistry 9 13%
Neuroscience 8 12%
Agricultural and Biological Sciences 8 12%
Pharmacology, Toxicology and Pharmaceutical Science 7 10%
Psychology 6 9%
Other 13 19%
Unknown 18 26%