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Light-Dependent Translocation of Visual Arrestin Regulated by the NINAC Myosin III

Overview of attention for article published in Neuron, July 2004
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Title
Light-Dependent Translocation of Visual Arrestin Regulated by the NINAC Myosin III
Published in
Neuron, July 2004
DOI 10.1016/j.neuron.2004.06.014
Pubmed ID
Authors

Seung-Jae Lee, Craig Montell

Abstract

The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent on interaction with phosphoinositides (PIs). However, the basis for the requirement for PIs for light-dependent shuttling was unclear. Here, we demonstrated that the dynamic trafficking of Arr2 into the phototransducing compartment, the rhabdomere, required the eye-enriched myosin III, NINAC. We showed that defects in ninaC resulted in a long-term adaptation phenotype similar to that which occurred in arr2 mutants. The interaction between Arr2 and NINAC was PI dependent and NINAC bound directly to PIs. These data demonstrate that the light-dependent translocation of Arr2 into the rhabdomeres requires PI-mediated interactions between Arr2 and the NINAC myosin III.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
United States 1 3%
Iran, Islamic Republic of 1 3%
Netherlands 1 3%
Unknown 27 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 19%
Student > Bachelor 4 13%
Professor > Associate Professor 4 13%
Professor 4 13%
Student > Master 3 10%
Other 10 32%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 58%
Biochemistry, Genetics and Molecular Biology 4 13%
Neuroscience 4 13%
Unspecified 3 10%
Medicine and Dentistry 2 6%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2004.
All research outputs
#7,688,002
of 12,304,922 outputs
Outputs from Neuron
#6,027
of 7,144 outputs
Outputs of similar age
#7,376,782
of 11,683,269 outputs
Outputs of similar age from Neuron
#6,013
of 7,122 outputs
Altmetric has tracked 12,304,922 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,144 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.5. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 7,122 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.