Title |
sigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice
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Published in |
BMC Microbiology, August 2012
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DOI | 10.1186/1471-2180-12-179 |
Pubmed ID | |
Authors |
Sarah E Barchinger, Xuqing Zhang, Sara E Hester, Maria E Rodriguez, Eric T Harvill, Sarah E Ades |
Abstract |
The cell envelope of a bacterial pathogen can be damaged by harsh conditions in the environment outside a host and by immune factors during infection. Cell envelope stress responses preserve the integrity of this essential compartment and are often required for virulence. Bordetella species are important respiratory pathogens that possess a large number of putative transcription factors. However, no cell envelope stress responses have been described in these species. Among the putative Bordetella transcription factors are a number of genes belonging to the extracytoplasmic function (ECF) group of alternative sigma factors, some of which are known to mediate cell envelope stress responses in other bacteria. Here we investigate the role of one such gene, sigE, in stress survival and pathogenesis of Bordetella bronchiseptica. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 25% |
Professor | 4 | 20% |
Student > Ph. D. Student | 3 | 15% |
Student > Master | 2 | 10% |
Other | 1 | 5% |
Other | 2 | 10% |
Unknown | 3 | 15% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 5 | 25% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Mathematics | 1 | 5% |
Medicine and Dentistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 4 | 20% |