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sigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice

Overview of attention for article published in BMC Microbiology, August 2012
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Title
sigE facilitates the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice
Published in
BMC Microbiology, August 2012
DOI 10.1186/1471-2180-12-179
Pubmed ID
Authors

Sarah E Barchinger, Xuqing Zhang, Sara E Hester, Maria E Rodriguez, Eric T Harvill, Sarah E Ades

Abstract

The cell envelope of a bacterial pathogen can be damaged by harsh conditions in the environment outside a host and by immune factors during infection. Cell envelope stress responses preserve the integrity of this essential compartment and are often required for virulence. Bordetella species are important respiratory pathogens that possess a large number of putative transcription factors. However, no cell envelope stress responses have been described in these species. Among the putative Bordetella transcription factors are a number of genes belonging to the extracytoplasmic function (ECF) group of alternative sigma factors, some of which are known to mediate cell envelope stress responses in other bacteria. Here we investigate the role of one such gene, sigE, in stress survival and pathogenesis of Bordetella bronchiseptica.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 25%
Professor 4 20%
Student > Ph. D. Student 3 15%
Student > Master 2 10%
Other 1 5%
Other 2 10%
Unknown 3 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 35%
Immunology and Microbiology 5 25%
Biochemistry, Genetics and Molecular Biology 2 10%
Mathematics 1 5%
Medicine and Dentistry 1 5%
Other 0 0%
Unknown 4 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2012.
All research outputs
#20,194,150
of 22,711,242 outputs
Outputs from BMC Microbiology
#2,674
of 3,171 outputs
Outputs of similar age
#133,936
of 149,526 outputs
Outputs of similar age from BMC Microbiology
#35
of 41 outputs
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.