Title |
Myeloid-Derived Suppressor Cells
|
---|---|
Published in |
Cancer Immunology Research, January 2017
|
DOI | 10.1158/2326-6066.cir-16-0297 |
Pubmed ID | |
Authors |
Dmitry I. Gabrilovich |
Abstract |
Myeloid cells developed evolutionarily as a major mechanism to protect the host. They evolved as a critical barrier against infections and are important contributors to tissue remodeling. However, in cancer, myeloid cells are largely converted to serve a new master-tumor cells. This process is epitomized by myeloid-derived suppressor cells (MDSC). These cells are closely related to neutrophils and monocytes. MDSCs are not present in the steady state of healthy individuals and appear in cancer and in pathologic conditions associated with chronic inflammation or stress. These cells have emerged as an important contributor to tumor progression. Ample evidence supports a key role for MDSCs in immune suppression in cancer, as well as their prominent role in tumor angiogenesis, drug resistance, and promotion of tumor metastases. MDSCs have a fascinating biology and are implicated in limiting the effects of cancer immunotherapy. Therefore, targeting these cells may represent an attractive therapeutic opportunity. Cancer Immunol Res; 5(1); 3-8. ©2016 AACR. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 5 | 45% |
United States | 2 | 18% |
India | 1 | 9% |
Unknown | 3 | 27% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 73% |
Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Scientists | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 904 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 169 | 19% |
Researcher | 132 | 15% |
Student > Bachelor | 118 | 13% |
Student > Master | 91 | 10% |
Student > Doctoral Student | 56 | 6% |
Other | 82 | 9% |
Unknown | 256 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 167 | 18% |
Immunology and Microbiology | 150 | 17% |
Medicine and Dentistry | 127 | 14% |
Agricultural and Biological Sciences | 86 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 33 | 4% |
Other | 61 | 7% |
Unknown | 280 | 31% |