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Inflammation

Overview of attention for book
Cover of 'Inflammation'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Reproducibility Issues: Avoiding Pitfalls in Animal Inflammation Models
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    Chapter 2 Hapten-Specific T Cell-Mediated Skin Inflammation: Flow Cytometry Analysis of Mouse Skin Inflammatory Infiltrate
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    Chapter 3 Monitoring Skin Dendritic Cells in Steady State and Inflammation by Immunofluorescence Microscopy and Flow Cytometry
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    Chapter 4 Visualization of the T Cell Response in Contact Hypersensitivity
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    Chapter 5 Ultraviolet Radiation-Induced Immunosuppression: Induction of Regulatory T Cells
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    Chapter 6 Surgical Denervation in the Imiquimod-Induced Psoriasiform Mouse Model
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    Chapter 7 Xenotransplantation Model of Psoriasis
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    Chapter 8 A Mouse Model for Atopic Dermatitis Using Topical Application of Vitamin D3 or of Its Analog MC903
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    Chapter 9 Particle Bombardment of Ex Vivo Skin to Deliver DNA and Express Proteins
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    Chapter 10 Murine Models of Allergic Asthma
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    Chapter 11 Subcutaneous and Sublingual Immunotherapy in a Mouse Model of Allergic Asthma
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    Chapter 12 Characterization of Group 2 Innate Lymphoid Cells in Allergic Airway Inflammation Models in the Mouse
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    Chapter 13 Induction and Analysis of Bronchus-Associated Lymphoid Tissue
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    Chapter 14 Messenger RNA Sequencing of Rare Cell Populations in the Lung and Lung-Draining Lymph Nodes
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    Chapter 15 Isolation and Identification of Intestinal Myeloid Cells
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    Chapter 16 Monitoring and Modulation of Inducible Foxp3+ Regulatory T-Cell Differentiation in the Lymph Nodes Draining the Small Intestine and Colon
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    Chapter 17 Isolation and Flow Cytometry Analysis of Innate Lymphoid Cells from the Intestinal Lamina Propria
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    Chapter 18 Analysis of Leukocytes in Oral Mucosal Tissues
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    Chapter 19 Optimized Mouse Models for Liver Fibrosis
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    Chapter 20 Monitoring of Chemically Induced Colitis
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    Chapter 21 Oxazolone-Induced Intestinal Inflammation in Adult Zebrafish
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    Chapter 22 High Dimensional Cytometry of Central Nervous System Leukocytes During Neuroinflammation
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    Chapter 23 Isolation of Microglia and Immune Infiltrates from Mouse and Primate Central Nervous System
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    Chapter 24 Investigating the Lymphatic Drainage of the Brain: Essential Skills and Tools
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    Chapter 25 Quantitative Assessment of Cerebral Basement Membranes Using Electron Microscopy
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    Chapter 26 Microglial Activation by Genetically Targeted Conditional Neuronal Ablation in the Zebrafish
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    Chapter 27 Experimental Arthritis Mouse Models Driven by Adaptive and/or Innate Inflammation
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    Chapter 28 Pain Relief in Nonhuman Primate Models of Arthritis
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    Chapter 29 Isolation and Characterization of Aortic Dendritic Cells and Lymphocytes in Atherosclerosis
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    Chapter 30 Assessment of Vascular Dysfunction and Inflammation Induced by Angiotensin II in Mice
  32. Altmetric Badge
    Chapter 31 Erratum to: Isolation and Characterization of Aortic Dendritic Cells and Lymphocytes in Atherosclerosis
Attention for Chapter 10: Murine Models of Allergic Asthma
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Chapter title
Murine Models of Allergic Asthma
Chapter number 10
Book title
Inflammation
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6786-5_10
Pubmed ID
Book ISBNs
978-1-4939-6784-1, 978-1-4939-6786-5
Authors

Eline Haspeslagh, Nincy Debeuf, Hamida Hammad, Bart N. Lambrecht, Haspeslagh, Eline, Debeuf, Nincy, Hammad, Hamida, Lambrecht, Bart N.

Editors

Björn E. Clausen, Jon D. Laman

Abstract

Allergic asthma is a heterogeneous inflammatory lung disease affecting millions of people worldwide and with a steadily increasing incidence. Mouse models have been of utmost importance in uncovering key inflammatory cell types, cytokines, and pathways in the development and maintenance of allergic asthma. Historically, the mainstay in experimental asthma research was sensitizing rodents to the model protein antigen ovalbumin (OVA) with the pro-Th2 adjuvant aluminum hydroxide, followed by repetitive OVA exposures to the airways to initiate a Th2-skewed adaptive immune response leading to eosinophilic airway inflammation and airway hyperreactivity (AHR). In the last 5 years, OVA is often replaced by naturally occurring allergens such as house dust mite (HDM) or cockroach extracts, but the principle of first sensitizing and then repetitively challenging mice with the same antigen is unchanged. Here, we describe an often used and relevant HDM-based protocol to establish acute allergic asthma, and the methods we have developed to rapidly analyze inflammatory cell infiltration in the bronchalveolar lavage fluid by flow cytometry. Moreover, we explain the methods to restimulate T cells from lung-draining mediastinal lymph nodes with HDM to allow the measurement of cytokine secretion profiles of allergen reactive T cells.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 1%
Unknown 82 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 19%
Researcher 12 14%
Student > Bachelor 11 13%
Student > Master 9 11%
Student > Doctoral Student 6 7%
Other 15 18%
Unknown 14 17%
Readers by discipline Count As %
Immunology and Microbiology 20 24%
Biochemistry, Genetics and Molecular Biology 14 17%
Agricultural and Biological Sciences 12 14%
Medicine and Dentistry 11 13%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Other 3 4%
Unknown 19 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2018.
All research outputs
#14,311,050
of 22,931,367 outputs
Outputs from Methods in molecular biology
#4,205
of 13,127 outputs
Outputs of similar age
#229,678
of 420,713 outputs
Outputs of similar age from Methods in molecular biology
#367
of 1,074 outputs
Altmetric has tracked 22,931,367 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,127 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,713 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,074 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.