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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease
|
|---|---|
| Published in |
Nature Genetics, January 2017
|
| DOI | 10.1038/ng.3755 |
| Pubmed ID | |
| Authors |
James C Lee, Daniele Biasci, Rebecca Roberts, Richard B Gearry, John C Mansfield, Tariq Ahmad, Natalie J Prescott, Jack Satsangi, David C Wilson, Luke Jostins, Carl A Anderson, James A Traherne, Paul A Lyons, Miles Parkes, Kenneth G C Smith |
| Abstract |
For most immune-mediated diseases, the main determinant of patient well-being is not the diagnosis itself but instead the course that the disease takes over time (prognosis). Prognosis may vary substantially between patients for reasons that are poorly understood. Familial studies support a genetic contribution to prognosis, but little evidence has been found for a proposed association between prognosis and the burden of susceptibility variants. To better characterize how genetic variation influences disease prognosis, we performed a within-cases genome-wide association study in two cohorts of patients with Crohn's disease. We identified four genome-wide significant loci, none of which showed any association with disease susceptibility. Conversely, the aggregated effect of all 170 disease susceptibility loci was not associated with disease prognosis. Together, these data suggest that the genetic contribution to prognosis in Crohn's disease is largely independent of the contribution to disease susceptibility and point to a biology of prognosis that could provide new therapeutic opportunities. |
X Demographics
The data shown below were collected from the profiles of 65 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 19 | 29% |
| United States | 12 | 18% |
| Switzerland | 3 | 5% |
| New Zealand | 2 | 3% |
| Japan | 1 | 2% |
| Denmark | 1 | 2% |
| Belgium | 1 | 2% |
| Guinea | 1 | 2% |
| Canada | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 23 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 45 | 69% |
| Scientists | 15 | 23% |
| Practitioners (doctors, other healthcare professionals) | 3 | 5% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 348 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| United Kingdom | 2 | <1% |
| Korea, Republic of | 1 | <1% |
| Hungary | 1 | <1% |
| Israel | 1 | <1% |
| Qatar | 1 | <1% |
| Unknown | 340 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 71 | 20% |
| Student > Ph. D. Student | 70 | 20% |
| Student > Master | 29 | 8% |
| Student > Bachelor | 27 | 8% |
| Other | 19 | 5% |
| Other | 62 | 18% |
| Unknown | 70 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 80 | 23% |
| Medicine and Dentistry | 75 | 22% |
| Agricultural and Biological Sciences | 41 | 12% |
| Immunology and Microbiology | 23 | 7% |
| Computer Science | 11 | 3% |
| Other | 30 | 9% |
| Unknown | 88 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 147. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2021.
All research outputs
#262,964
of 24,397,600 outputs
Outputs from Nature Genetics
#498
of 7,409 outputs
Outputs of similar age
#5,949
of 429,825 outputs
Outputs of similar age from Nature Genetics
#16
of 72 outputs
Altmetric has tracked 24,397,600 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,409 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 429,825 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.