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The Essential Medicinal Chemistry of Curcumin

Overview of attention for article published in Journal of Medicinal Chemistry, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 19,574)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
64 news outlets
blogs
25 blogs
twitter
493 tweeters
patent
2 patents
facebook
34 Facebook pages
wikipedia
3 Wikipedia pages
googleplus
6 Google+ users
reddit
6 Redditors
video
4 video uploaders

Citations

dimensions_citation
549 Dimensions

Readers on

mendeley
1108 Mendeley
citeulike
1 CiteULike
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Title
The Essential Medicinal Chemistry of Curcumin
Published in
Journal of Medicinal Chemistry, January 2017
DOI 10.1021/acs.jmedchem.6b00975
Pubmed ID
Authors

Kathryn M. Nelson, Jayme L. Dahlin, Jonathan Bisson, James Graham, Guido F. Pauli, Michael A. Walters

Abstract

Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed.

Twitter Demographics

The data shown below were collected from the profiles of 493 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Australia 2 <1%
Brazil 1 <1%
Italy 1 <1%
Netherlands 1 <1%
France 1 <1%
India 1 <1%
United Kingdom 1 <1%
Mexico 1 <1%
Other 2 <1%
Unknown 1095 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 196 18%
Student > Master 175 16%
Student > Ph. D. Student 170 15%
Researcher 132 12%
Other 63 6%
Other 200 18%
Unknown 172 16%
Readers by discipline Count As %
Chemistry 215 19%
Biochemistry, Genetics and Molecular Biology 137 12%
Agricultural and Biological Sciences 122 11%
Pharmacology, Toxicology and Pharmaceutical Science 109 10%
Medicine and Dentistry 96 9%
Other 183 17%
Unknown 246 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1043. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2021.
All research outputs
#6,668
of 16,651,954 outputs
Outputs from Journal of Medicinal Chemistry
#1
of 19,574 outputs
Outputs of similar age
#230
of 391,623 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#1
of 93 outputs
Altmetric has tracked 16,651,954 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 19,574 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 391,623 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.