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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Essential Medicinal Chemistry of Curcumin
|
|---|---|
| Published in |
Journal of Medicinal Chemistry, January 2017
|
| DOI | 10.1021/acs.jmedchem.6b00975 |
| Pubmed ID | |
| Authors |
Kathryn M. Nelson, Jayme L. Dahlin, Jonathan Bisson, James Graham, Guido F. Pauli, Michael A. Walters |
| Abstract |
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed. |
X Demographics
The data shown below were collected from the profiles of 625 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 107 | 17% |
| Japan | 46 | 7% |
| India | 31 | 5% |
| United Kingdom | 22 | 4% |
| Canada | 17 | 3% |
| France | 9 | 1% |
| Germany | 8 | 1% |
| Spain | 8 | 1% |
| Mongolia | 8 | 1% |
| Other | 86 | 14% |
| Unknown | 283 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 467 | 75% |
| Scientists | 118 | 19% |
| Practitioners (doctors, other healthcare professionals) | 27 | 4% |
| Science communicators (journalists, bloggers, editors) | 11 | 2% |
| Unknown | 2 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,869 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Australia | 2 | <1% |
| Switzerland | 1 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 1857 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 280 | 15% |
| Student > Master | 250 | 13% |
| Student > Ph. D. Student | 213 | 11% |
| Researcher | 173 | 9% |
| Other | 83 | 4% |
| Other | 301 | 16% |
| Unknown | 569 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 275 | 15% |
| Biochemistry, Genetics and Molecular Biology | 201 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 170 | 9% |
| Agricultural and Biological Sciences | 148 | 8% |
| Medicine and Dentistry | 134 | 7% |
| Other | 277 | 15% |
| Unknown | 664 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1210. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2024.
All research outputs
#11,849
of 25,761,363 outputs
Outputs from Journal of Medicinal Chemistry
#1
of 23,295 outputs
Outputs of similar age
#199
of 426,007 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#1
of 129 outputs
Altmetric has tracked 25,761,363 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 23,295 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 426,007 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.