Title |
Precision epigenetics provides a scalable pathway for improving coronary heart disease care globally
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Published in |
Epigenomics, September 2023
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DOI | 10.2217/epi-2023-0233 |
Pubmed ID | |
Authors |
Damon Broyles, Robert Philibert |
Abstract |
Coronary heart disease (CHD) is the world's leading cause of death. Up to 90% of all CHD deaths are preventable, but effective prevention of this mortality requires more scalable, precise methods for assessing CHD status and monitoring treatment response. Unfortunately, current diagnostic methods have barriers to implementation, particularly in rural areas and lower-income countries. This gap may be bridged by highly scalable advances in DNA methylation testing methods and artificial intelligence. Herein, we review prior studies of CHD related to methylation alone and in combination with other biovariables. We compare these new methods with established methods for diagnosing CHD. Finally, we outline pathways through which methylation-based testing methods may allow the democratization of improved methods for assessing CHD globally. |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
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Unknown | 4 | 100% |
Demographic breakdown
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Student > Doctoral Student | 1 | 25% |
Student > Ph. D. Student | 1 | 25% |
Other | 1 | 25% |
Unknown | 1 | 25% |
Readers by discipline | Count | As % |
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Arts and Humanities | 1 | 25% |
Biochemistry, Genetics and Molecular Biology | 1 | 25% |
Medicine and Dentistry | 1 | 25% |
Unknown | 1 | 25% |