Report for: ZBTB33 binds unmethylated regions of the genome associated with actively expressed genes

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Title	ZBTB33 binds unmethylated regions of the genome associated with actively expressed genes
Published in	Epigenetics & Chromatin, January 2013
DOI	10.1186/1756-8935-6-13
Pubmed ID	23693142
Authors	Adam Blattler, Lijing Yao, Yao Wang, Zhenqing Ye, Victor X Jin, Peggy J Farnham
Abstract	DNA methylation and repressive histone modifications cooperate to silence promoters. One mechanism by which regions of methylated DNA could acquire repressive histone modifications is via methyl DNA-binding transcription factors. The zinc finger protein ZBTB33 (also known as Kaiso) has been shown in vitro to bind preferentially to methylated DNA and to interact with the SMRT/NCoR histone deacetylase complexes. We have performed bioinformatic analyses of Kaiso ChIP-seq and DNA methylation datasets to test a model whereby binding of Kaiso to methylated CpGs leads to loss of acetylated histones at target promoters.

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Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United States	5	8%
Czechia	1	2%
Unknown	54	90%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	21	35%
Researcher	11	18%
Student > Master	9	15%
Student > Bachelor	7	12%
Student > Doctoral Student	5	8%
Other	7	12%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	31	52%
Biochemistry, Genetics and Molecular Biology	19	32%
Medicine and Dentistry	2	3%
Computer Science	2	3%
Neuroscience	2	3%
Other	4	7%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2013.

All research outputs

#1,932,975

of 12,470,444 outputs

Outputs from Epigenetics & Chromatin

#109

of 359 outputs

Outputs of similar age

#24,167

of 147,573 outputs

Outputs of similar age from Epigenetics & Chromatin

of 3 outputs

Altmetric has tracked 12,470,444 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 359 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has gotten more attention than average, scoring higher than 69% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 147,573 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.

We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them

ZBTB33 binds unmethylated regions of the genome associated with actively expressed genes

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Attention Score in Context