Title |
ZBTB33 binds unmethylated regions of the genome associated with actively expressed genes
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Published in |
Epigenetics & Chromatin, January 2013
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DOI | 10.1186/1756-8935-6-13 |
Pubmed ID | |
Authors |
Adam Blattler, Lijing Yao, Yao Wang, Zhenqing Ye, Victor X Jin, Peggy J Farnham |
Abstract |
DNA methylation and repressive histone modifications cooperate to silence promoters. One mechanism by which regions of methylated DNA could acquire repressive histone modifications is via methyl DNA-binding transcription factors. The zinc finger protein ZBTB33 (also known as Kaiso) has been shown in vitro to bind preferentially to methylated DNA and to interact with the SMRT/NCoR histone deacetylase complexes. We have performed bioinformatic analyses of Kaiso ChIP-seq and DNA methylation datasets to test a model whereby binding of Kaiso to methylated CpGs leads to loss of acetylated histones at target promoters. |
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