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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease
|
|---|---|
| Published in |
Journal of Neuroinflammation, January 2017
|
| DOI | 10.1186/s12974-016-0779-0 |
| Pubmed ID | |
| Authors |
Charbel Moussa, Michaeline Hebron, Xu Huang, Jaeil Ahn, Robert A. Rissman, Paul S. Aisen, R. Scott Turner |
| Abstract |
Treatment of mild-moderate Alzheimer's disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and activities of daily living (ADL) scores. For this retrospective study, we examined banked CSF and plasma samples from a subset of AD subjects with CSF Aβ42 <600 ng/ml (biomarker-confirmed AD) at baseline (N = 19 resveratrol-treated and N = 19 placebo-treated). We utilized multiplex Xmap technology to measure markers of neurodegenerative disease and metalloproteinases (MMPs) in parallel in CSF and plasma samples. Compared to the placebo-treated group, at 52 weeks, resveratrol markedly reduced CSF MMP9 and increased macrophage-derived chemokine (MDC), interleukin (IL)-4, and fibroblast growth factor (FGF)-2. Compared to baseline, resveratrol increased plasma MMP10 and decreased IL-12P40, IL12P70, and RANTES. In this subset analysis, resveratrol treatment attenuated declines in mini-mental status examination (MMSE) scores, change in ADL (ADCS-ADL) scores, and CSF Aβ42 levels during the 52-week trial, but did not alter tau levels. Collectively, these data suggest that resveratrol decreases CSF MMP9, modulates neuro-inflammation, and induces adaptive immunity. SIRT1 activation may be a viable target for treatment or prevention of neurodegenerative disorders. ClinicalTrials.gov NCT01504854. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 37% |
| United Kingdom | 2 | 11% |
| Mexico | 2 | 11% |
| Australia | 1 | 5% |
| Madagascar | 1 | 5% |
| Unknown | 6 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 89% |
| Scientists | 2 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 540 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 539 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 86 | 16% |
| Student > Master | 70 | 13% |
| Researcher | 46 | 9% |
| Student > Ph. D. Student | 46 | 9% |
| Other | 23 | 4% |
| Other | 85 | 16% |
| Unknown | 184 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 74 | 14% |
| Medicine and Dentistry | 46 | 9% |
| Neuroscience | 44 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 36 | 7% |
| Nursing and Health Professions | 33 | 6% |
| Other | 96 | 18% |
| Unknown | 211 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 71. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2023.
All research outputs
#604,964
of 25,503,365 outputs
Outputs from Journal of Neuroinflammation
#47
of 2,959 outputs
Outputs of similar age
#12,771
of 423,086 outputs
Outputs of similar age from Journal of Neuroinflammation
#3
of 36 outputs
Altmetric has tracked 25,503,365 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,959 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 423,086 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.