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Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states

Overview of attention for article published in Nature Medicine, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#24 of 6,604)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Citations

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83 Dimensions

Readers on

mendeley
268 Mendeley
citeulike
5 CiteULike
Title
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
Published in
Nature Medicine, January 2017
DOI 10.1038/nm.4267
Pubmed ID
Authors

David Furman, Junlei Chang, Lydia Lartigue, Christopher R Bolen, François Haddad, Brice Gaudilliere, Edward A Ganio, Gabriela K Fragiadakis, Matthew H Spitzer, Isabelle Douchet, Sophie Daburon, Jean-François Moreau, Garry P Nolan, Patrick Blanco, Julie Déchanet-Merville, Cornelia L Dekker, Vladimir Jojic, Calvin J Kuo, Mark M Davis, Benjamin Faustin

Abstract

Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear. Inflammasomes can drive chronic inflammation in the context of an infectious disease or cellular stress, and they trigger the maturation of interleukin-1β (IL-1β). Here we find that the expression of specific inflammasome gene modules stratifies older individuals into two extremes: those with constitutive expression of IL-1β, nucleotide metabolism dysfunction, elevated oxidative stress, high rates of hypertension and arterial stiffness; and those without constitutive expression of IL-1β, who lack these characteristics. Adenine and N(4)-acetylcytidine, nucleotide-derived metabolites that are detectable in the blood of the former group, prime and activate the NLRC4 inflammasome, induce the production of IL-1β, activate platelets and neutrophils and elevate blood pressure in mice. In individuals over 85 years of age, the elevated expression of inflammasome gene modules was associated with all-cause mortality. Thus, targeting inflammasome components may ameliorate chronic inflammation and various other age-associated conditions.

Twitter Demographics

The data shown below were collected from the profiles of 156 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 268 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 4 1%
United States 3 1%
France 2 <1%
Japan 2 <1%
Switzerland 1 <1%
Norway 1 <1%
Belgium 1 <1%
Sweden 1 <1%
Unknown 253 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 73 27%
Student > Ph. D. Student 54 20%
Student > Master 24 9%
Unspecified 22 8%
Student > Doctoral Student 18 7%
Other 77 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 67 25%
Medicine and Dentistry 50 19%
Biochemistry, Genetics and Molecular Biology 45 17%
Unspecified 37 14%
Immunology and Microbiology 33 12%
Other 36 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 866. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2019.
All research outputs
#5,114
of 13,209,822 outputs
Outputs from Nature Medicine
#24
of 6,604 outputs
Outputs of similar age
#290
of 343,113 outputs
Outputs of similar age from Nature Medicine
#1
of 67 outputs
Altmetric has tracked 13,209,822 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,604 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,113 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.