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NADPH oxidase in brain injury and neurodegenerative disorders

Overview of attention for article published in Molecular Neurodegeneration, January 2017
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2 tweeters

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123 Mendeley
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Title
NADPH oxidase in brain injury and neurodegenerative disorders
Published in
Molecular Neurodegeneration, January 2017
DOI 10.1186/s13024-017-0150-7
Pubmed ID
Authors

Merry W. Ma, Jing Wang, Quanguang Zhang, Ruimin Wang, Krishnan M. Dhandapani, Ratna K. Vadlamudi, Darrell W. Brann

Abstract

Oxidative stress is a common denominator in the pathology of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis, as well as in ischemic and traumatic brain injury. The brain is highly vulnerable to oxidative damage due to its high metabolic demand. However, therapies attempting to scavenge free radicals have shown little success. By shifting the focus to inhibit the generation of damaging free radicals, recent studies have identified NADPH oxidase as a major contributor to disease pathology. NADPH oxidase has the primary function to generate free radicals. In particular, there is growing evidence that the isoforms NOX1, NOX2, and NOX4 can be upregulated by a variety of neurodegenerative factors. The majority of recent studies have shown that genetic and pharmacological inhibition of NADPH oxidase enzymes are neuroprotective and able to reduce detrimental aspects of pathology following ischemic and traumatic brain injury, as well as in chronic neurodegenerative disorders. This review aims to summarize evidence supporting the role of NADPH oxidase in the pathology of these neurological disorders, explores pharmacological strategies of targeting this major oxidative stress pathway, and outlines obstacles that need to be overcome for successful translation of these therapies to the clinic.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Austria 1 <1%
Unknown 122 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 34 28%
Student > Master 18 15%
Student > Bachelor 14 11%
Researcher 12 10%
Student > Doctoral Student 8 7%
Other 22 18%
Unknown 15 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 23%
Neuroscience 21 17%
Agricultural and Biological Sciences 21 17%
Medicine and Dentistry 10 8%
Pharmacology, Toxicology and Pharmaceutical Science 8 7%
Other 19 15%
Unknown 16 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2019.
All research outputs
#8,040,567
of 13,968,403 outputs
Outputs from Molecular Neurodegeneration
#418
of 585 outputs
Outputs of similar age
#164,492
of 346,911 outputs
Outputs of similar age from Molecular Neurodegeneration
#5
of 6 outputs
Altmetric has tracked 13,968,403 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 585 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,911 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.