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Systemic Immunity Is Required for Effective Cancer Immunotherapy

Overview of attention for article published in Cell, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
11 news outlets
blogs
2 blogs
twitter
232 tweeters
facebook
9 Facebook pages

Citations

dimensions_citation
403 Dimensions

Readers on

mendeley
1049 Mendeley
citeulike
3 CiteULike
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Title
Systemic Immunity Is Required for Effective Cancer Immunotherapy
Published in
Cell, January 2017
DOI 10.1016/j.cell.2016.12.022
Pubmed ID
Authors

Matthew H. Spitzer, Yaron Carmi, Nathan E. Reticker-Flynn, Serena S. Kwek, Deepthi Madhireddy, Maria M. Martins, Pier Federico Gherardini, Tyler R. Prestwood, Jonathan Chabon, Sean C. Bendall, Lawrence Fong, Garry P. Nolan, Edgar G. Engleman

Abstract

Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass cytometry. We analyzed immune responses in several tissues after immunotherapy by developing intuitive models for visualizing single-cell data with statistical inference. Immune activation was evident in the tumor and systemically shortly after effective therapy was administered. However, during tumor rejection, only peripheral immune cells sustained their proliferation. This systemic response was coordinated across tissues and required for tumor eradication in several immunotherapy models. An emergent population of peripheral CD4 T cells conferred protection against new tumors and was significantly expanded in patients responding to immunotherapy. These studies demonstrate the critical impact of systemic immune responses that drive tumor rejection.

Twitter Demographics

The data shown below were collected from the profiles of 232 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 1,049 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 <1%
France 4 <1%
Sweden 2 <1%
Israel 2 <1%
United Kingdom 2 <1%
Korea, Republic of 1 <1%
Switzerland 1 <1%
Australia 1 <1%
Austria 1 <1%
Other 4 <1%
Unknown 1024 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 280 27%
Student > Ph. D. Student 247 24%
Student > Master 80 8%
Other 79 8%
Student > Bachelor 63 6%
Other 169 16%
Unknown 131 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 220 21%
Immunology and Microbiology 212 20%
Biochemistry, Genetics and Molecular Biology 194 18%
Medicine and Dentistry 135 13%
Engineering 31 3%
Other 80 8%
Unknown 177 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 220. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2021.
All research outputs
#96,936
of 17,995,569 outputs
Outputs from Cell
#620
of 15,721 outputs
Outputs of similar age
#3,365
of 368,096 outputs
Outputs of similar age from Cell
#17
of 135 outputs
Altmetric has tracked 17,995,569 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,721 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 368,096 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.