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Systemic Immunity Is Required for Effective Cancer Immunotherapy

Overview of attention for article published in Cell, January 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
11 news outlets
blogs
2 blogs
twitter
238 tweeters
facebook
8 Facebook pages

Citations

dimensions_citation
93 Dimensions

Readers on

mendeley
464 Mendeley
citeulike
3 CiteULike
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Title
Systemic Immunity Is Required for Effective Cancer Immunotherapy
Published in
Cell, January 2017
DOI 10.1016/j.cell.2016.12.022
Pubmed ID
Authors

Matthew H. Spitzer, Yaron Carmi, Nathan E. Reticker-Flynn, Serena S. Kwek, Deepthi Madhireddy, Maria M. Martins, Pier Federico Gherardini, Tyler R. Prestwood, Jonathan Chabon, Sean C. Bendall, Lawrence Fong, Garry P. Nolan, Edgar G. Engleman, Spitzer, Matthew H., Carmi, Yaron, Reticker-Flynn, Nathan E., Kwek, Serena S., Madhireddy, Deepthi, Martins, Maria M., Gherardini, Pier Federico, Prestwood, Tyler R., Chabon, Jonathan, Bendall, Sean C., Fong, Lawrence, Nolan, Garry P., Engleman, Edgar G.

Abstract

Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass cytometry. We analyzed immune responses in several tissues after immunotherapy by developing intuitive models for visualizing single-cell data with statistical inference. Immune activation was evident in the tumor and systemically shortly after effective therapy was administered. However, during tumor rejection, only peripheral immune cells sustained their proliferation. This systemic response was coordinated across tissues and required for tumor eradication in several immunotherapy models. An emergent population of peripheral CD4 T cells conferred protection against new tumors and was significantly expanded in patients responding to immunotherapy. These studies demonstrate the critical impact of systemic immune responses that drive tumor rejection.

Twitter Demographics

The data shown below were collected from the profiles of 238 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 464 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 1%
France 3 <1%
United Kingdom 3 <1%
Germany 1 <1%
Australia 1 <1%
Denmark 1 <1%
China 1 <1%
Japan 1 <1%
Korea, Republic of 1 <1%
Other 2 <1%
Unknown 444 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 132 28%
Student > Ph. D. Student 128 28%
Student > Bachelor 36 8%
Other 36 8%
Student > Master 31 7%
Other 101 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 132 28%
Immunology and Microbiology 98 21%
Biochemistry, Genetics and Molecular Biology 78 17%
Medicine and Dentistry 70 15%
Unspecified 37 8%
Other 49 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 228. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2018.
All research outputs
#42,603
of 11,602,242 outputs
Outputs from Cell
#252
of 14,156 outputs
Outputs of similar age
#2,868
of 324,381 outputs
Outputs of similar age from Cell
#14
of 148 outputs
Altmetric has tracked 11,602,242 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,156 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,381 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 148 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.