| Chapter title |
GPR56 interacts with extracellular matrix and regulates cancer progression.
|
|---|---|
| Chapter number | 8 |
| Book title |
Adhesion-GPCRs
|
| Published in |
Advances in experimental medicine and biology, January 2010
|
| DOI | 10.1007/978-1-4419-7913-1_8 |
| Pubmed ID | |
| Book ISBNs |
978-1-4419-7912-4, 978-1-4419-7913-1
|
| Authors |
Lei Xu, Xu, Lei |
| Abstract |
GPR56 is a relatively recent addition to the adhesion-GPCR family. Genetic and biochemical studies uncovered its roles in cancer and development and established its function as an adhesion receptor to mediate the interactions between cells and extracellular matrix. Despite of much progress on understanding its biological implications, the mechanism of its function remains elusive. It has not been firmly established whether GPR56 signals directly through G proteins and what its upstream stimuli and downstream effectors are to execute its various biological effects. This chapter will give an overview of the primary structures of the Gpr56 gene and its encoded protein and attempt to point out open questions in this research area, with an emphasis on its roles in cancer and signal transduction. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | 12% |
| Unknown | 15 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 18% |
| Student > Ph. D. Student | 3 | 18% |
| Student > Doctoral Student | 2 | 12% |
| Other | 1 | 6% |
| Student > Bachelor | 1 | 6% |
| Other | 4 | 24% |
| Unknown | 3 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 35% |
| Biochemistry, Genetics and Molecular Biology | 5 | 29% |
| Medicine and Dentistry | 2 | 12% |
| Immunology and Microbiology | 1 | 6% |
| Unknown | 3 | 18% |