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Immunotherapy in endometrial cancer - an evolving therapeutic paradigm

Overview of attention for article published in Gynecologic Oncology Research and Practice, December 2015
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66 Mendeley
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Title
Immunotherapy in endometrial cancer - an evolving therapeutic paradigm
Published in
Gynecologic Oncology Research and Practice, December 2015
DOI 10.1186/s40661-015-0020-3
Pubmed ID
Authors

Teresa C. Longoria, Ramez N. Eskander

Abstract

Endometrial cancer is the only gynecologic malignancy with a rising incidence and mortality. While cure is routinely achieved with surgery alone or in combination with adjuvant pelvic radiotherapy when disease is confined to the uterus, patients with metastatic or recurrent disease exhibit limited response rates to cytotoxic chemotherapy, targeted agents, or hormonal therapy. Given the unmet clinical need in this patient population, exploration of novel therapeutic approaches is warranted, and attention is turning to immunomodulation of the tumor microenvironment. Existing evidence suggests that endometrial cancer is sufficiently immunogenic to be a reasonable candidate for active and/or passive immunotherapy. In this review, we critically examine what is known about the microenvironment in endometrial cancer and what has been learned from preliminary immunotherapy trials that enrolled endometrial cancer patients, encouraging further attempts at immunomodulation in the treatment of aggressive forms of this disease.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 65 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 20%
Student > Master 9 14%
Researcher 8 12%
Student > Ph. D. Student 6 9%
Student > Doctoral Student 5 8%
Other 13 20%
Unknown 12 18%
Readers by discipline Count As %
Medicine and Dentistry 27 41%
Biochemistry, Genetics and Molecular Biology 9 14%
Agricultural and Biological Sciences 5 8%
Immunology and Microbiology 3 5%
Materials Science 2 3%
Other 4 6%
Unknown 16 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2018.
All research outputs
#14,908,193
of 22,940,083 outputs
Outputs from Gynecologic Oncology Research and Practice
#24
of 34 outputs
Outputs of similar age
#216,240
of 388,161 outputs
Outputs of similar age from Gynecologic Oncology Research and Practice
#1
of 1 outputs
Altmetric has tracked 22,940,083 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 34 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one scored the same or higher as 10 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 388,161 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them