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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa
|
|---|---|
| Published in |
Nature Structural & Molecular Biology, June 2013
|
| DOI | 10.1038/nsmb.2599 |
| Pubmed ID | |
| Authors |
Serap Erkek, Mizue Hisano, Ching-Yeu Liang, Mark Gill, Rabih Murr, Jürgen Dieker, Dirk Schübeler, Johan van der Vlag, Michael B Stadler, Antoine H F M Peters |
| Abstract |
In mammalian spermatozoa, most but not all of the genome is densely packaged by protamines. Here we reveal the molecular logic underlying the retention of nucleosomes in mouse spermatozoa, which contain only 1% residual histones. We observe high enrichment throughout the genome of nucleosomes at CpG-rich sequences that lack DNA methylation. Residual nucleosomes are largely composed of the histone H3.3 variant and are trimethylated at Lys4 of histone H3 (H3K4me3). Canonical H3.1 and H3.2 histones are also enriched at CpG-rich promoters marked by Polycomb-mediated H3K27me3, a modification predictive of gene repression in preimplantation embryos. Histone variant-specific nucleosome retention in sperm is strongly associated with nucleosome turnover in round spermatids. Our data show evolutionary conservation of the basic principles of nucleosome retention in mouse and human sperm, supporting a model of epigenetic inheritance by nucleosomes between generations. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 308 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Japan | 2 | <1% |
| Norway | 1 | <1% |
| India | 1 | <1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Portugal | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 297 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 75 | 24% |
| Researcher | 71 | 23% |
| Student > Master | 26 | 8% |
| Student > Bachelor | 19 | 6% |
| Student > Doctoral Student | 16 | 5% |
| Other | 56 | 18% |
| Unknown | 45 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 124 | 40% |
| Biochemistry, Genetics and Molecular Biology | 93 | 30% |
| Medicine and Dentistry | 12 | 4% |
| Neuroscience | 7 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | <1% |
| Other | 19 | 6% |
| Unknown | 50 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2019.
All research outputs
#2,926,633
of 25,837,817 outputs
Outputs from Nature Structural & Molecular Biology
#1,136
of 4,240 outputs
Outputs of similar age
#23,150
of 199,308 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#14
of 51 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,240 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,308 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.