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Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer’s disease dementia

Overview of attention for article published in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), January 2017
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Title
Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer’s disease dementia
Published in
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), January 2017
DOI 10.1590/1516-4446-2016-1991
Pubmed ID
Authors

Fabricio F. de Oliveira, Elizabeth S. Chen, Marilia C. Smith, Paulo H. Bertolucci

Abstract

To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer's disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. Considering 201 patients, only APOE-ɛ4 carriers had earlier dementia onset in multiple correlations, as well as less apathy, more delusions, and more aberrant motor behavior. Both ACE polymorphisms were associated with less intense frontally mediated behaviors. Regarding LDLR variants, carriers of the A allele of rs11669576 had less anxiety and more aberrant motor behavior, whereas carriers of the A allele of rs5930 had less delusions, less anxiety, more apathy, and more irritability. CETP variants that included G alleles of I422V and TaqIB were mostly associated with less intense frontally mediated behaviors, while severely impaired carriers of the T allele of rs2695121 had more anxiety and more aberrant motor behavior. Though only APOE haplotypes affected AD onset, cerebrovascular metabolism genotypes were associated with differences in several neuropsychiatric manifestations of AD.

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Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 21%
Student > Master 11 19%
Researcher 6 10%
Student > Ph. D. Student 6 10%
Student > Doctoral Student 3 5%
Other 4 7%
Unknown 16 28%
Readers by discipline Count As %
Medicine and Dentistry 10 17%
Psychology 8 14%
Agricultural and Biological Sciences 5 9%
Neuroscience 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 6 10%
Unknown 22 38%