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Annexin A1 protein regulates the expression of PMVEC cytoskeletal proteins in CBDL rat serum-induced pulmonary microvascular remodeling

Overview of attention for article published in Journal of Translational Medicine, April 2013
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Title
Annexin A1 protein regulates the expression of PMVEC cytoskeletal proteins in CBDL rat serum-induced pulmonary microvascular remodeling
Published in
Journal of Translational Medicine, April 2013
DOI 10.1186/1479-5876-11-98
Pubmed ID
Authors

Bin Yi, Jing Zeng, Guansong Wang, Guisheng Qian, Kaizhi Lu

Abstract

Hepatopulmonary syndrome (HPS) is characterized by advanced liver disease, hypoxemia and intrapulmonary vascular dilatation (IPVD). The pathogenesis of HPS is not completely understood. Recent findings have established the role of proliferation and phenotype differentiation of pulmonary microvascular endothelial cells (PMVECs) in IPVD of HPS; the change in cytoskeletal proteins and their molecular mechanism play an essential role in the proliferation, phenotype modulation and differentiation of PMVECs. However, little is known about the relevance of cytoskeletal protein expression and its molecular mechanism in IPVD of HPS. In addition, ANX A1 protein has been identified as a key regulator in some important signaling pathways, which influences cytoskeletal remodeling in many diseases, such as lung cancer, liver cancer, etc.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 11%
Student > Master 3 7%
Student > Postgraduate 2 5%
Other 1 2%
Professor 1 2%
Other 3 7%
Unknown 29 66%
Readers by discipline Count As %
Medicine and Dentistry 6 14%
Biochemistry, Genetics and Molecular Biology 2 5%
Agricultural and Biological Sciences 2 5%
Psychology 1 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 2 5%
Unknown 30 68%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2013.
All research outputs
#18,340,605
of 22,712,476 outputs
Outputs from Journal of Translational Medicine
#2,942
of 3,973 outputs
Outputs of similar age
#149,331
of 197,218 outputs
Outputs of similar age from Journal of Translational Medicine
#47
of 50 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,973 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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