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Whole exome sequencing of adenoid cystic carcinoma

Overview of attention for article published in Journal of Clinical Investigation, June 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

news
3 news outlets
blogs
1 blog
twitter
2 tweeters
patent
1 patent
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
148 Dimensions

Readers on

mendeley
106 Mendeley
citeulike
2 CiteULike
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Title
Whole exome sequencing of adenoid cystic carcinoma
Published in
Journal of Clinical Investigation, June 2013
DOI 10.1172/jci67201
Pubmed ID
Authors

Philip J. Stephens, Helen R. Davies, Yoshitsugu Mitani, Peter Van Loo, Adam Shlien, Patrick S. Tarpey, Elli Papaemmanuil, Angela Cheverton, Graham R. Bignell, Adam P. Butler, John Gamble, Stephen Gamble, Claire Hardy, Jonathan Hinton, Mingming Jia, Alagu Jayakumar, David Jones, Calli Latimer, Stuart McLaren, David J. McBride, Andrew Menzies, Laura Mudie, Mark Maddison, Keiran Raine, Serena Nik-Zainal, Sarah O’Meara, Jon W. Teague, Ignacio Varela, David C. Wedge, Ian Whitmore, Scott M. Lippman, Ultan McDermott, Michael R. Stratton, Peter J. Campbell, Adel K. El-Naggar, P. Andrew Futreal

Abstract

Adenoid cystic carcinoma (ACC) is a rare malignancy that can occur in multiple organ sites and is primarily found in the salivary gland. While the identification of recurrent fusions of the MYB-NFIB genes have begun to shed light on the molecular underpinnings, little else is known about the molecular genetics of this frequently fatal cancer. We have undertaken exome sequencing in a series of 24 ACC to further delineate the genetics of the disease. We identified multiple mutated genes that, combined, implicate chromatin deregulation in half of cases. Further, mutations were identified in known cancer genes, including PIK3CA, ATM, CDKN2A, SF3B1, SUFU, TSC1, and CYLD. Mutations in NOTCH1/2 were identified in 3 cases, and we identify the negative NOTCH signaling regulator, SPEN, as a new cancer gene in ACC with mutations in 5 cases. Finally, the identification of 3 likely activating mutations in the tyrosine kinase receptor FGFR2, analogous to those reported in ovarian and endometrial carcinoma, point to potential therapeutic avenues for a subset of cases.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Poland 1 <1%
United States 1 <1%
Sweden 1 <1%
Canada 1 <1%
Unknown 102 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 25%
Student > Ph. D. Student 22 21%
Unspecified 12 11%
Student > Doctoral Student 9 8%
Student > Postgraduate 8 8%
Other 28 26%
Readers by discipline Count As %
Medicine and Dentistry 36 34%
Agricultural and Biological Sciences 30 28%
Biochemistry, Genetics and Molecular Biology 19 18%
Unspecified 17 16%
Computer Science 2 2%
Other 2 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2018.
All research outputs
#409,141
of 13,343,384 outputs
Outputs from Journal of Clinical Investigation
#628
of 13,255 outputs
Outputs of similar age
#5,183
of 152,363 outputs
Outputs of similar age from Journal of Clinical Investigation
#28
of 126 outputs
Altmetric has tracked 13,343,384 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,255 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,363 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.