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Effect of nitric oxide synthase inhibition on the exchange of glucose and fatty acids in human skeletal muscle

Overview of attention for article published in Nutrition & Metabolism, January 2013
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  • Good Attention Score compared to outputs of the same age (75th percentile)

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8 tweeters


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20 Mendeley
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Effect of nitric oxide synthase inhibition on the exchange of glucose and fatty acids in human skeletal muscle
Published in
Nutrition & Metabolism, January 2013
DOI 10.1186/1743-7075-10-43
Pubmed ID

Ilkka Heinonen, Bengt Saltin, Jukka Kemppainen, Pirjo Nuutila, Juhani Knuuti, Kari Kalliokoski, Ylva Hellsten


The role of nitric oxide in controlling substrate metabolism in humans is incompletely understood. The present study examined the effect of nitric oxide blockade on glucose uptake, and free fatty acid and lactate exchange in skeletal muscle of eight healthy young males. Exchange was determined by measurements of muscle perfusion by positron emission tomography and analysis of arterial and femoral venous plasma concentrations of glucose, fatty acids and lactate. The measurements were performed at rest and during exercise without (control) and with blockade of nitric oxide synthase (NOS) with NG-monomethyl-l-arginine (L-NMMA). Glucose uptake at rest was 0.40 ± 0.21 μmol/100 g/min and increased to 3.71 ± 2.53 μmol/100 g/min by acute one leg low intensity exercise (p < 0.01). Prior inhibition of NOS by L-NMMA did not affect glucose uptake, at rest or during exercise (0.40 ± 0.26 and 4.74 ± 2.69 μmol/100 g/min, respectively). In the control trial, there was a small release of free fatty acids from the limb at rest (-0.05 ± 0.09 μmol/100 g/min), whereas during inhibition of NOS, there was a small uptake of fatty acids (0.04 ± 0.05 μmol/100 g/min, p < 0.05). During exercise fatty acid uptake was increased to (0.89 ± 1.07 μmol/100 g/min), and there was a non-significant trend (p = 0.10) for an increased FFA uptake with NOS inhibition 1.23 ± 1.48 μmol/100 g/min) compared to the control condition. Arterial concentrations of all substrates and exchange of lactate over the limb at rest and during exercise remained unaltered during the two conditions. In conclusion, inhibition of nitric oxide synthesis does not alter muscle glucose uptake during low intensity exercise, but affects free fatty acid exchange especially at rest, and may thus be involved in the modulation of energy metabolism in the human skeletal muscle.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 25%
Researcher 5 25%
Professor 2 10%
Other 1 5%
Student > Bachelor 1 5%
Other 4 20%
Unknown 2 10%
Readers by discipline Count As %
Medicine and Dentistry 4 20%
Agricultural and Biological Sciences 3 15%
Biochemistry, Genetics and Molecular Biology 2 10%
Psychology 1 5%
Sports and Recreations 1 5%
Other 2 10%
Unknown 7 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2018.
All research outputs
of 13,343,384 outputs
Outputs from Nutrition & Metabolism
of 677 outputs
Outputs of similar age
of 152,353 outputs
Outputs of similar age from Nutrition & Metabolism
of 1 outputs
Altmetric has tracked 13,343,384 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 677 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.3. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,353 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them