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Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Overview of attention for article published in Journal of Biology, January 2003
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#18 of 107)
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Citations

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1205 Dimensions

Readers on

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363 Mendeley
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Title
Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade
Published in
Journal of Biology, January 2003
DOI 10.1186/1475-4924-2-28
Pubmed ID
Authors

Hawley, Simon A, Boudeau, Jérôme, Reid, Jennifer L, Mustard, Kirsty J, Udd, Lina, Mäkelä, Tomi P, Alessi, Dario R, Hardie, D Grahame, Simon A Hawley, Jérôme Boudeau, Jennifer L Reid, Kirsty J Mustard, Lina Udd, Tomi P Mäkelä, Dario R Alessi, D Grahame Hardie

Abstract

The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires phosphorylation of Thr172 of AMPK within the activation loop by upstream kinases (AMPKKs) that have not been identified. Recently, we identified three related protein kinases acting upstream of the yeast homolog of AMPK. Although they do not have obvious mammalian homologs, they are related to LKB1, a tumor suppressor that is mutated in the human Peutz-Jeghers cancer syndrome. We recently showed that LKB1 exists as a complex with two accessory subunits, STRAD alpha/beta and MO25 alpha/beta.

Mendeley readers

The data shown below were compiled from readership statistics for 363 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Germany 2 <1%
France 2 <1%
Japan 2 <1%
South Africa 1 <1%
Belgium 1 <1%
China 1 <1%
Sweden 1 <1%
Hungary 1 <1%
Other 0 0%
Unknown 349 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 102 28%
Student > Master 51 14%
Researcher 49 13%
Student > Bachelor 48 13%
Professor > Associate Professor 29 8%
Other 55 15%
Unknown 29 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 151 42%
Biochemistry, Genetics and Molecular Biology 83 23%
Medicine and Dentistry 40 11%
Chemistry 9 2%
Pharmacology, Toxicology and Pharmaceutical Science 7 2%
Other 28 8%
Unknown 45 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2013.
All research outputs
#1,359,470
of 13,358,614 outputs
Outputs from Journal of Biology
#18
of 107 outputs
Outputs of similar age
#1,311,666
of 12,707,259 outputs
Outputs of similar age from Journal of Biology
#18
of 105 outputs
Altmetric has tracked 13,358,614 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 107 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 12,707,259 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.