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A Functional Variant at 19q13.3, rs967591G>A, is associated with shorter Survival of Early-Stage Lung Cancer

Overview of attention for article published in Clinical Cancer Research, August 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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4 tweeters

Citations

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9 Dimensions

Readers on

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8 Mendeley
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Title
A Functional Variant at 19q13.3, rs967591G>A, is associated with shorter Survival of Early-Stage Lung Cancer
Published in
Clinical Cancer Research, August 2013
DOI 10.1158/1078-0432.ccr-12-2792
Pubmed ID
Authors

Hyo-Sung Jeon, Guang Jin, Hyo-Gyoung Kang, Yi Young Choi, Won-Kee Lee, Jin-Eun Choi, Eun Young Bae, Seung Soo Yoo, Shin Yup Lee, Eung Bae Lee, Young Tae Kim, Jaehee Lee, Sung-Ick Cha, Chang-Ho Kim, Sanghoon Jheon, In-San Kim, Jae Yong Park, H.-S. Jeon, G. Jin, H.-G. Kang, Y. Y. Choi, W. K. Lee, J. E. Choi, E. Y. Bae, S. S. Yoo, S. Y. Lee, E. B. Lee, Y. T. Kim, J. Lee, S.-I. Cha, C. H. Kim, S. Jheon, I. S. Kim, J. Y. Park

Abstract

This study was conducted to investigate the associations between single-nucleotide polymorphisms (SNP) in 19q13.3 and survival of patients with early-stage non-small cell lung cancer (NSCLC), and to define the causative functional SNP of the association. A two-stage study design was used to evaluate five SNPs in relation to survival outcomes in 328 patients and then to validate the results in an independent patient population (n = 483). Luciferase assay and real-time PCR were conducted to examine functional relevance of a potentially functional SNP. Of the five SNPs, three SNPs (rs105165C>T, rs967591G>A, and rs735482A>C) were significantly associated with survival outcomes in a stage I study. The rs967591A allele had significantly higher activity of the CD3EAP promoter compared with the rs967591G allele (P = 0.002), but the SNP did not have an effect on the activity of PPP1R13L promoter. The rs967591G>A was associated with the level of CD3EAP mRNA expression in lung tissues (P = 0.01). The rs967591G>A exhibited consistent associations in a stage II study. In combined analysis, the rs967591 AA genotype exhibited a worse overall survival (adjusted HR = 1.69; 95% confidence interval = 1.29-2.20; P = 0.0001). The rs967591G>A affects CD3EAP expression and thus influences survival in early-stage NSCLC. The analysis of the rs967591G>A polymorphism can help identify patients at high risk of a poor disease outcome.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Professor 2 25%
Researcher 2 25%
Student > Postgraduate 1 13%
Student > Ph. D. Student 1 13%
Other 1 13%
Other 1 13%
Readers by discipline Count As %
Medicine and Dentistry 3 38%
Biochemistry, Genetics and Molecular Biology 2 25%
Agricultural and Biological Sciences 2 25%
Unspecified 1 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2013.
All research outputs
#6,298,529
of 11,281,639 outputs
Outputs from Clinical Cancer Research
#5,837
of 8,379 outputs
Outputs of similar age
#57,366
of 133,251 outputs
Outputs of similar age from Clinical Cancer Research
#2
of 8 outputs
Altmetric has tracked 11,281,639 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,379 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 133,251 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.