Title |
Do current screening recommendations allow for early detection of lithium-induced hyperparathyroidism in patients with bipolar disorder?
|
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Published in |
International Journal of Bipolar Disorders, June 2013
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DOI | 10.1186/2194-7511-1-7 |
Pubmed ID | |
Authors |
Michael Berger, Michael Riedel, Nora Tomova, Michael Obermeier, Florian Seemüller, Sandra Dittmann, Hans-Jürgen Moeller, Emanuel Severus |
Abstract |
Current screening recommendations for early detection of lithium-associated hyperparathyroidism propose an exclusive measurement of serum albumin-adjusted calcium (Aac) concentration as a single first step. However, longitudinal data in patients with recurrent affective disorders suggest that increases in serum intact parathyroid hormone (iPTH) levels in lithium-treated patients may not necessarily be accompanied by a parallel increase in the concentration of Aac. If true, patients with an isolated increase in iPTH concentration above the reference range might be missed following current screening recommendations. Therefore, this study set out to examine key parameters of calcium metabolism, including iPTH and 25-hydroxycholecalciferol concentrations in patients with bipolar disorder that was or was not managed with lithium. |
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Mendeley readers
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