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Apolipoprotein-E genotype and human immunodeficiency virus-associated neurocognitive disorder: the modulating effects of older age and disease severity

Overview of attention for article published in Neurobehavioral HIV medicine, June 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)

Mentioned by

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3 tweeters
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1 Facebook page

Citations

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18 Dimensions

Readers on

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17 Mendeley
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Title
Apolipoprotein-E genotype and human immunodeficiency virus-associated neurocognitive disorder: the modulating effects of older age and disease severity
Published in
Neurobehavioral HIV medicine, June 2013
DOI 10.2147/nbhiv.s39573
Pubmed ID
Authors

Stella Panos, Hinkin, Elyse Singer, April Thames, Patel, Sinsheimer, Del Re, Benjamin Gelman, Moore, Andrew Levine, Morgello

Abstract

The apolipoprotein-E (APOE) ε4 allele is a risk factor for vascular dementia and Alzheimer's disease. Recent studies are equivocal with regards to whether or not the ε4 allele confers increased risk for the development of human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND), but suggest that age and/or disease severity may be modulating factors. The aim of this study was to assess the interactions and contributions of APOE genotype, age, and HIV disease severity as risk factors for HAND in HIV-infected adults. Participants were 259 HIV-positive individuals who underwent APOE genotyping, a standardized neurological evaluation, a comprehensive neuropsychological evaluation, and laboratory testing. Older ε4 carriers showed a higher frequency of HAND compared with age-matched non-ε4 carriers. Analysis by discrete neurocognitive domain revealed that advanced age modulated the effect of the ε4 allele, such that older ε4 allele carriers showed reduced executive functioning and information processing speed. Exploratory analyses assessing the relationship between ε4 and disease severity in the overall sample revealed that disease severity modulated the effect of the ε4 allele on cognition. Lower absolute CD4+ cell count among ε4 allele carriers was associated with poorer working memory ability. Advancing age and degree of immunosuppression may influence the association between APOE ε4 allele status and HAND. These two factors need to be taken into account in future research.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 6%
Unknown 16 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 29%
Professor > Associate Professor 3 18%
Student > Bachelor 2 12%
Student > Master 2 12%
Professor 1 6%
Other 3 18%
Unknown 1 6%
Readers by discipline Count As %
Psychology 6 35%
Biochemistry, Genetics and Molecular Biology 2 12%
Medicine and Dentistry 2 12%
Agricultural and Biological Sciences 2 12%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Other 2 12%
Unknown 2 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2013.
All research outputs
#1,950,434
of 4,505,482 outputs
Outputs from Neurobehavioral HIV medicine
#3
of 12 outputs
Outputs of similar age
#36,269
of 89,486 outputs
Outputs of similar age from Neurobehavioral HIV medicine
#1
of 1 outputs
Altmetric has tracked 4,505,482 research outputs across all sources so far. This one has received more attention than most of these and is in the 55th percentile.
So far Altmetric has tracked 12 research outputs from this source. They receive a mean Attention Score of 1.2. This one scored the same or higher as 9 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 89,486 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them