Title |
Prediabetic changes in gene expression induced by aspartame and monosodium glutamate in Trans fat-fed C57Bl/6 J mice
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Published in |
Nutrition & Metabolism, June 2013
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DOI | 10.1186/1743-7075-10-44 |
Pubmed ID | |
Authors |
Kate S Collison, Nadine J Makhoul, Marya Z Zaidi, Angela Inglis, Bernard L Andres, Rosario Ubungen, Soad Saleh, Futwan A Al-Mohanna |
Abstract |
The human diet has altered markedly during the past four decades, with the introduction of Trans hydrogenated fat, which extended the shelf-life of dietary oils and promoted a dramatic increase in elaidic acid (Trans-18.1) consumption. Food additives such as monosodium glutamate (MSG) and aspartame (ASP) were introduced to increase food palatability and reduce caloric intake. Nutrigenomics studies in small-animal models are an established platform for analyzing the interactions between various macro- and micronutrients. We therefore investigated the effects of changes in hepatic and adipose tissue gene expression induced by the food additives ASP, MSG or a combination of both additives in C57Bl/6 J mice fed a Trans fat-enriched diet. |
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