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The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates

Overview of attention for article published in Chemistry - A European Journal, June 2013
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Title
The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates
Published in
Chemistry - A European Journal, June 2013
DOI 10.1002/chem.201301463
Pubmed ID
Authors

Therése Klingstedt, Hamid Shirani, K. O. Andreas Åslund, Nigel J. Cairns, Christina J. Sigurdson, Michel Goedert, K. Peter R. Nilsson

Abstract

Protein misfolding diseases are characterized by deposition of protein aggregates, and optical ligands for molecular characterization of these disease-associated structures are important for understanding their potential role in the pathogenesis of the disease. Luminescent conjugated oligothiophenes (LCOs) have proven useful for optical identification of a broader subset of disease-associated protein aggregates than conventional ligands, such as thioflavin T and Congo red. Herein, the molecular requirements for achieving LCOs able to detect nonthioflavinophilic Aβ aggregates or non-congophilic prion aggregates, as well as spectrally discriminate Aβ and tau aggregates, were investigated. An anionic pentameric LCO was subjected to chemical engineering by: 1) replacing thiophene units with selenophene or phenylene moieties, or 2) alternating the anionic substituents along the thiophene backbone. In addition, two asymmetric tetrameric ligands were generated. Overall, the results from this study identified conformational freedom and extended conjugation of the conjugated backbone as crucial determinants for obtaining superior thiophene-based optical ligands for sensitive detection and spectral assignment of disease-associated protein aggregates.

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Lithuania 1 2%
United States 1 2%
Belgium 1 2%
Unknown 57 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 34%
Researcher 14 23%
Student > Master 8 13%
Student > Bachelor 7 11%
Unspecified 3 5%
Other 9 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 29%
Chemistry 18 29%
Biochemistry, Genetics and Molecular Biology 7 11%
Neuroscience 7 11%
Engineering 3 5%
Other 9 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2013.
All research outputs
#10,801,691
of 12,183,333 outputs
Outputs from Chemistry - A European Journal
#9,316
of 11,921 outputs
Outputs of similar age
#119,526
of 142,757 outputs
Outputs of similar age from Chemistry - A European Journal
#120
of 133 outputs
Altmetric has tracked 12,183,333 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,921 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 142,757 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.