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The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice

Overview of attention for article published in BMC Neuroscience, January 2017
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  • Above-average Attention Score compared to outputs of the same age (61st percentile)

Mentioned by

6 tweeters
1 video uploader


18 Dimensions

Readers on

36 Mendeley
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The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice
Published in
BMC Neuroscience, January 2017
DOI 10.1186/s12868-016-0312-5
Pubmed ID

Elise Siegert, Friedemann Paul, Michael Rothe, Karsten H. Weylandt


There is a large body of experimental evidence suggesting that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are capable of modulating immune function. Some studies have shown that these PUFAs might have a beneficial effect in patients suffering form multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system (CNS). This could be due to increased n-3 PUFA-derived anti-inflammatory lipid mediators. In the present study we tested the effect of an endogenously increased n-3 PUFA status on cuprizone-induced CNS demyelination and remyelination in fat-1 mice versus their wild-type (wt) littermates. Fat-1 mice express an n-3 desaturase, which allows them to convert n-6 PUFAs into n-3 PUFAs. CNS lipid profiles in fat-1 mice showed a significant increase of eicosapentaenoic acid (EPA) levels but similar docosahexaenoic acid levels compared to wt littermates. This was also reflected in significantly higher levels of monohydroxy EPA metabolites such as 18-hydroxyeicosapentaenoic acid (18-HEPE) in fat-1 brain tissue. Feeding fat-1 mice and wt littermates 0.2% cuprizone for 5 weeks caused a similar degree of CNS demyelination in both groups; remyelination was increased in the fat-1 group after a recovery period of 2 weeks. However, at p = 0.07 this difference missed statistical significance. These results indicate that n-3 PUFAs might have a role in promotion of remyelination after toxic injury to CNS oligodendrocytes. This might occur either via modulation of the immune system or via a direct effect on oligodendrocytes or neurons through EPA-derived lipid metabolites such as 18-HEPE.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 22%
Student > Master 6 17%
Student > Bachelor 4 11%
Professor 3 8%
Student > Doctoral Student 3 8%
Other 5 14%
Unknown 7 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 22%
Medicine and Dentistry 5 14%
Neuroscience 4 11%
Nursing and Health Professions 2 6%
Social Sciences 2 6%
Other 7 19%
Unknown 8 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2018.
All research outputs
of 14,378,609 outputs
Outputs from BMC Neuroscience
of 1,066 outputs
Outputs of similar age
of 349,621 outputs
Outputs of similar age from BMC Neuroscience
of 1 outputs
Altmetric has tracked 14,378,609 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,066 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,621 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them