Title |
Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma
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Published in |
Diagnostic Pathology, June 2013
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DOI | 10.1186/1746-1596-8-103 |
Pubmed ID | |
Authors |
Xiao-Man Li, Xu-Yong Lin, Hong-Tao Xu, Juan-Han Yu, Liang Wang, Chui-Feng Fan, Yang Liu, En-Hua Wang |
Abstract |
Epithelioid hemangioendothelioma is a relatively uncommon lesion usually presenting in soft tissues. The occurrence in the mediastinum is exceptional rare. Histologically, this tumor is characterized by epithelioid cells with intracytoplasmic vacuole s in a hyalinized or mucinous stroma. Occasionally, spindle cells or osteoclast-like giant cel ls can be observed. Herein, we present a case of epithelioid hemangioendothelioma in a 38 year-old Chinese male. The tumor was predominantly composed of abundant spindle cells with marked atypia and scattered osteoclast-like giant cells reminiscent of malignant fibrous histiocytoma. The unusual histological appearance can pose a great diagnostic challenge. It may be easily misdiagnosed, especially if the specimen is limited or from fine-needle aspiration. Virtual slides http://www.diagnosticpathology.diagnomx.eu/vs/8287357528177060. |
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