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d-Cycloserine enhances durability of social skills training in autism spectrum disorder

Overview of attention for article published in Molecular Autism, January 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)

Mentioned by

twitter
15 tweeters
facebook
2 Facebook pages
video
1 video uploader

Citations

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14 Dimensions

Readers on

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65 Mendeley
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Title
d-Cycloserine enhances durability of social skills training in autism spectrum disorder
Published in
Molecular Autism, January 2017
DOI 10.1186/s13229-017-0116-1
Pubmed ID
Authors

Logan K. Wink, Noha F. Minshawi, Rebecca C. Shaffer, Martin H. Plawecki, David J. Posey, Paul S. Horn, Ryan Adams, Ernest V. Pedapati, Tori L. Schaefer, Christopher J. McDougle, Naomi B. Swiezy, Craig A. Erickson

Abstract

d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability. Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single doses of 50 mg of DCS or placebo administered 30 min prior to group social skills training. Following the 10-week active treatment phase, blinded follow-up assessments occurred at week 11 and week 22. The primary outcome measure for our durability of treatment evaluation was the parent-rated social responsiveness scale (SRS) total raw score at week 22. Analysis of the SRS total raw score demonstrated significant decrease for the DCS group compared to the placebo group (p = 0.042) indicating greater maintenance of treatment effect in the DCS group. DCS was well tolerated, with irritability being the most frequently reported adverse effect in both groups. The findings of this study suggest that DCS may help youth with ASD to maintain skills gained during sort-term social skills training. Larger-scale studies with longer follow-up will be necessary to further understand the long-term impact of DCS paired with structured social skills training. ClinicalTrials.gov, NCT01086475.

Twitter Demographics

The data shown below were collected from the profiles of 15 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 65 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 23%
Student > Master 9 14%
Student > Ph. D. Student 9 14%
Student > Bachelor 6 9%
Student > Doctoral Student 3 5%
Other 9 14%
Unknown 14 22%
Readers by discipline Count As %
Psychology 20 31%
Medicine and Dentistry 6 9%
Social Sciences 5 8%
Nursing and Health Professions 4 6%
Neuroscience 3 5%
Other 8 12%
Unknown 19 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2018.
All research outputs
#1,673,051
of 14,585,616 outputs
Outputs from Molecular Autism
#198
of 467 outputs
Outputs of similar age
#53,626
of 349,751 outputs
Outputs of similar age from Molecular Autism
#2
of 4 outputs
Altmetric has tracked 14,585,616 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.6. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,751 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.