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Molecular Pathogenesis and Signal Transduction by Helicobacter pylori

Overview of attention for book
Cover of 'Molecular Pathogenesis and Signal Transduction by Helicobacter pylori'

Table of Contents

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    Book Overview
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    Chapter 1 The Human Stomach in Health and Disease: Infection Strategies by Helicobacter pylori
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    Chapter 2 Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases
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    Chapter 3 Immune Evasion Strategies and Persistence of Helicobacter pylori
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    Chapter 4 Recent Advances in Helicobacter pylori Replication: Possible Implications in Adaptation to a Pathogenic Lifestyle and Perspectives for Drug Design
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    Chapter 5 The Helicobacter pylori Methylome: Roles in Gene Regulation and Virulence
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    Chapter 6 Structural Insights into Helicobacter pylori Cag Protein Interactions with Host Cell Factors
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    Chapter 7 Gastric Organoids: An Emerging Model System to Study Helicobacter pylori Pathogenesis
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    Chapter 8 DNA Transfer and Toll-like Receptor Modulation by Helicobacter pylori
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    Chapter 9 Exploiting the Gastric Epithelial Barrier: Helicobacter pylori’s Attack on Tight and Adherens Junctions
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    Chapter 10 Helicobacter pylori-Induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease
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    Chapter 11 Impact of the Microbiota and Gastric Disease Development by Helicobacter pylori
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    Chapter 12 Pathogenesis of Gastric Cancer: Genetics and Molecular Classification
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    Chapter 13 Helicobacter pylori-Mediated Genetic Instability and Gastric Carcinogenesis
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    Chapter 14 Helicobacter pylori and Extragastric Diseases
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    Chapter 15 Erratum to: Pathogenesis of Gastric Cancer: Genetics and Molecular Classification
Attention for Chapter 13: Helicobacter pylori-Mediated Genetic Instability and Gastric Carcinogenesis
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Chapter title
Helicobacter pylori-Mediated Genetic Instability and Gastric Carcinogenesis
Chapter number 13
Book title
Molecular Pathogenesis and Signal Transduction by Helicobacter pylori
Published in
Current topics in microbiology and immunology, January 2017
DOI 10.1007/978-3-319-50520-6_13
Pubmed ID
28124159
Book ISBNs
978-3-31-950519-0, 978-3-31-950520-6
Authors

Takahiro Shimizu, Tsutomu Chiba, Hiroyuki Marusawa, Shimizu, Takahiro, Chiba, Tsutomu, Marusawa, Hiroyuki

Editors

Nicole Tegtmeyer, Steffen Backert

Abstract

Helicobacter pylori infection is the most important cause of human gastric cancer worldwide. Gastric cancer develops over a long time after H. pylori infection via stepwise accumulation of genetic alterations and positive selection of cells with growth advantages. H. pylori itself and the resultant chronic inflammation lead to the emergence of genetic alterations in gastric epithelial cells via increased susceptibility of these cells to DNA damage. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) in inflammatory and gastric epithelial cells, as well as the expression of cytidine deaminase in gastric epithelial cells, may link H. pylori-related inflammation and DNA damage. Recent comprehensive analyses of gastric cancer genomes provide clues for the possible molecular mechanisms of gastric carcinogenesis. In this chapter, we describe how genetic alterations emerge during gastric carcinogenesis related to H. pylori infection.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 30%
Student > Doctoral Student 3 11%
Student > Master 3 11%
Other 2 7%
Student > Ph. D. Student 2 7%
Other 4 15%
Unknown 5 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 30%
Medicine and Dentistry 5 19%
Immunology and Microbiology 4 15%
Chemical Engineering 1 4%
Agricultural and Biological Sciences 1 4%
Other 3 11%
Unknown 5 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2017.
All research outputs
#19,594,120
of 24,093,053 outputs
Outputs from Current topics in microbiology and immunology
#546
of 688 outputs
Outputs of similar age
#318,321
of 425,767 outputs
Outputs of similar age from Current topics in microbiology and immunology
#34
of 37 outputs
Altmetric has tracked 24,093,053 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 688 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 425,767 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.

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