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A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

Overview of attention for article published in PLoS Genetics, June 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 7,627)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
12 news outlets
blogs
9 blogs
twitter
410 tweeters
peer_reviews
1 peer review site
facebook
105 Facebook pages
wikipedia
1 Wikipedia page
googleplus
24 Google+ users
reddit
4 Redditors

Citations

dimensions_citation
390 Dimensions

Readers on

mendeley
652 Mendeley
citeulike
7 CiteULike
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Title
A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue
Published in
PLoS Genetics, June 2013
DOI 10.1371/journal.pgen.1003572
Pubmed ID
Authors

Tina Rönn, Petr Volkov, Cajsa Davegårdh, Tasnim Dayeh, Elin Hall, Anders H. Olsson, Emma Nilsson, Åsa Tornberg, Marloes Dekker Nitert, Karl-Fredrik Eriksson, Helena A. Jones, Leif Groop, Charlotte Ling

Abstract

Epigenetic mechanisms are implicated in gene regulation and the development of different diseases. The epigenome differs between cell types and has until now only been characterized for a few human tissues. Environmental factors potentially alter the epigenome. Here we describe the genome-wide pattern of DNA methylation in human adipose tissue from 23 healthy men, with a previous low level of physical activity, before and after a six months exercise intervention. We also investigate the differences in adipose tissue DNA methylation between 31 individuals with or without a family history of type 2 diabetes. DNA methylation was analyzed using Infinium HumanMethylation450 BeadChip, an array containing 485,577 probes covering 99% RefSeq genes. Global DNA methylation changed and 17,975 individual CpG sites in 7,663 unique genes showed altered levels of DNA methylation after the exercise intervention (q<0.05). Differential mRNA expression was present in 1/3 of gene regions with altered DNA methylation, including RALBP1, HDAC4 and NCOR2 (q<0.05). Using a luciferase assay, we could show that increased DNA methylation in vitro of the RALBP1 promoter suppressed the transcriptional activity (p = 0.03). Moreover, 18 obesity and 21 type 2 diabetes candidate genes had CpG sites with differences in adipose tissue DNA methylation in response to exercise (q<0.05), including TCF7L2 (6 CpG sites) and KCNQ1 (10 CpG sites). A simultaneous change in mRNA expression was seen for 6 of those genes. To understand if genes that exhibit differential DNA methylation and mRNA expression in human adipose tissue in vivo affect adipocyte metabolism, we silenced Hdac4 and Ncor2 respectively in 3T3-L1 adipocytes, which resulted in increased lipogenesis both in the basal and insulin stimulated state. In conclusion, exercise induces genome-wide changes in DNA methylation in human adipose tissue, potentially affecting adipocyte metabolism.

Twitter Demographics

The data shown below were collected from the profiles of 410 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 652 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 9 1%
United Kingdom 7 1%
Portugal 3 <1%
Spain 3 <1%
Australia 3 <1%
Canada 3 <1%
Switzerland 2 <1%
Turkey 2 <1%
Germany 2 <1%
Other 12 2%
Unknown 606 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 145 22%
Researcher 110 17%
Student > Master 90 14%
Student > Bachelor 74 11%
Student > Doctoral Student 50 8%
Other 136 21%
Unknown 47 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 220 34%
Biochemistry, Genetics and Molecular Biology 136 21%
Medicine and Dentistry 109 17%
Sports and Recreations 22 3%
Nursing and Health Professions 17 3%
Other 79 12%
Unknown 69 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 540. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2020.
All research outputs
#23,552
of 17,418,198 outputs
Outputs from PLoS Genetics
#11
of 7,627 outputs
Outputs of similar age
#141
of 163,474 outputs
Outputs of similar age from PLoS Genetics
#1
of 141 outputs
Altmetric has tracked 17,418,198 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,627 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,474 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 141 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.