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Aggressive mature natural killer cell neoplasms: from epidemiology todiagnosis

Overview of attention for article published in Orphanet Journal of Rare Diseases, July 2013
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Title
Aggressive mature natural killer cell neoplasms: from epidemiology todiagnosis
Published in
Orphanet Journal of Rare Diseases, July 2013
DOI 10.1186/1750-1172-8-95
Pubmed ID
Authors

Margarida Lima

Abstract

Mature natural killer (NK) cell neoplasms are classified by the World Health Organization into NK/T cell lymphoma, nasal type (NKTCL), aggressive NK-cell leukemia (ANKCL) and chronic lymphoproliferative disorders of NK-cells, the latter being considered provisionally. NKTCL and ANKCL are rare diseases, with higher prevalence in Asia, Central and South America. Most NKTCL present extranodal, as a destructive tumor affecting the nose and upper aerodigestive tract (nasal NKTCL) or any organ or tissue (extranasal NKTCL) whereas ANKCL manifests as a systemic disease with multiorgan involvement and naturally evolutes to death in a few weeks. The histopathological hallmark of these aggressive NK-cell tumors is a polymorphic neoplastic infiltrate with angiocentricity, angiodestruction and tissue necrosis. The tumor cells have cytoplasmatic azurophilic granules and usually show a CD45(+bright), CD2(+), sCD3(-), cytCD3epsilon(+), CD56(+bright), CD16(−/+), cytotoxic granules molecules(+) phenotype. T-cell receptor genes are in germ-line configuration. Epstein-Barr virus (EBV) -encoded membrane proteins and early region EBV RNA are usually detected on lymphoma cells, with a pattern suggestive of a latent viral infection type II. Complex chromosomal abnormalities are frequent and loss of chromosomes 6q, 11q, 13q, and 17p are recurrent aberrations. The rarity of the NK-cell tumors limits our ability to standardize the procedures for the diagnosis and clinical management and efforts should be made to encourage multi-institutional registries.

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Mendeley readers

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The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Other 12 24%
Student > Postgraduate 7 14%
Student > Bachelor 7 14%
Researcher 5 10%
Student > Doctoral Student 2 4%
Other 7 14%
Unknown 9 18%
Readers by discipline Count As %
Medicine and Dentistry 27 55%
Biochemistry, Genetics and Molecular Biology 6 12%
Agricultural and Biological Sciences 2 4%
Engineering 2 4%
Immunology and Microbiology 1 2%
Other 1 2%
Unknown 10 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2013.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Orphanet Journal of Rare Diseases
#2,441
of 3,105 outputs
Outputs of similar age
#157,446
of 206,704 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#36
of 43 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,105 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
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We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.