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A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

Overview of attention for article published in Nature Genetics, June 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Citations

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157 Mendeley
Title
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci
Published in
Nature Genetics, June 2013
DOI 10.1038/ng.2686
Pubmed ID
Authors

David A Hinds, George McMahon, Amy K Kiefer, Chuong B Do, Nicholas Eriksson, David M Evans, Beate St Pourcain, Susan M Ring, Joanna L Mountain, Uta Francke, George Davey-Smith, Nicholas J Timpson, Joyce Y Tung

Abstract

Allergic disease is very common and carries substantial public-health burdens. We conducted a meta-analysis of genome-wide associations with self-reported cat, dust-mite and pollen allergies in 53,862 individuals. We used generalized estimating equations to model shared and allergy-specific genetic effects. We identified 16 shared susceptibility loci with association P<5×10(-8), including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6 and TLR10 (rs2101521, P=5.3×10(-21)); 6p21.33 near HLA-C and MICA (rs9266772, P=3.2×10(-12)); 5p13.1 near PTGER4 (rs7720838, P=8.2×10(-11)); 2q33.1 in PLCL1 (rs10497813, P=6.1×10(-10)), 3q28 in LPP (rs9860547, P=1.2×10(-9)); 20q13.2 in NFATC2 (rs6021270, P=6.9×10(-9)), 4q27 in ADAD1 (rs17388568, P=3.9×10(-8)); and 14q21.1 near FOXA1 and TTC6 (rs1998359, P=4.8×10(-8)). We identified one locus with substantial evidence of differences in effects across allergies at 6p21.32 in the class II human leukocyte antigen (HLA) region (rs17533090, P=1.7×10(-12)), which was strongly associated with cat allergy. Our study sheds new light on the shared etiology of immune and autoimmune disease.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 157 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 3%
Germany 2 1%
Netherlands 2 1%
Spain 1 <1%
Hungary 1 <1%
Canada 1 <1%
Unknown 146 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 47 30%
Researcher 38 24%
Student > Master 18 11%
Professor > Associate Professor 18 11%
Student > Doctoral Student 7 4%
Other 29 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 64 41%
Biochemistry, Genetics and Molecular Biology 27 17%
Medicine and Dentistry 27 17%
Unspecified 15 10%
Computer Science 5 3%
Other 19 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 139. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2016.
All research outputs
#80,193
of 11,590,749 outputs
Outputs from Nature Genetics
#242
of 5,861 outputs
Outputs of similar age
#950
of 134,363 outputs
Outputs of similar age from Nature Genetics
#5
of 73 outputs
Altmetric has tracked 11,590,749 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,861 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 134,363 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.