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ADAM23 is a common risk gene for canine idiopathic epilepsy

Overview of attention for article published in BMC Genetics, January 2017
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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3 tweeters
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4 Facebook pages

Citations

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5 Dimensions

Readers on

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29 Mendeley
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1 CiteULike
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Title
ADAM23 is a common risk gene for canine idiopathic epilepsy
Published in
BMC Genetics, January 2017
DOI 10.1186/s12863-017-0478-6
Pubmed ID
Authors

Lotta L. E. Koskinen, Eija H. Seppälä, Jutta Weissl, Tarja S. Jokinen, Ranno Viitmaa, Reetta L. Hänninen, Pascale Quignon, Andrea Fischer, Catherine André, Hannes Lohi

Abstract

Idiopathic or genetic adult-onset epilepsy is a common neurological disorder in domestic dogs. Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we performed genome-wide association (GWA) analyses in four new breeds, and investigated the association of the previously reported ADAM23 haplotype with the epilepsy phenotype in eight breeds. GWA analysis did not reveal new epilepsy loci. ADAM23 association (p < 0.05) was identified in five breeds. Combined analysis of all eight breeds showed significant association (p = 4.6e(-6), OR 1.9). Our results further support the role of ADAM23 in multiple breeds as a common risk gene for epilepsy with low penetrance. The lack of findings in the GWA analyses points towards inefficient capture of genetic variation by the current SNP arrays, causal variant(s) with low penetrance and possible phenocopies. Future work will include studies on ADAM23 function and expression in canine neurons, as well as whole-genome sequencing in order to identify additional IE genes.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 21%
Other 4 14%
Student > Bachelor 4 14%
Student > Doctoral Student 2 7%
Student > Postgraduate 2 7%
Other 8 28%
Unknown 3 10%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 13 45%
Biochemistry, Genetics and Molecular Biology 5 17%
Medicine and Dentistry 3 10%
Agricultural and Biological Sciences 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 0 0%
Unknown 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2017.
All research outputs
#6,350,180
of 11,339,407 outputs
Outputs from BMC Genetics
#313
of 776 outputs
Outputs of similar age
#146,120
of 320,711 outputs
Outputs of similar age from BMC Genetics
#9
of 14 outputs
Altmetric has tracked 11,339,407 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 776 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,711 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.