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Mesenchymal stem cells: key players in cancer progression

Overview of attention for article published in Molecular Cancer, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)

Mentioned by

twitter
13 tweeters

Citations

dimensions_citation
243 Dimensions

Readers on

mendeley
343 Mendeley
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Title
Mesenchymal stem cells: key players in cancer progression
Published in
Molecular Cancer, February 2017
DOI 10.1186/s12943-017-0597-8
Pubmed ID
Authors

Sarah M. Ridge, Francis J. Sullivan, Sharon A. Glynn

Abstract

Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, cells of the immune system and mesenchymal stem cells (MSCs). MSCs are multipotent stromal cells that are known to reside in various areas such as the bone marrow, fat and dental pulp. MSCs have been found to migrate towards inflammatory sites and studies have shown that they also migrate towards and incorporate into the tumour. The key question is how they interact there. MSCs may interact with tumour cells through paracrine signalling. On the other hand, MSCs have the capacity to differentiate to various cell types such as osteocytes, chondrocytes and adipocytes and it is possible that MSCs differentiate at the site of the tumour. More recently it has been shown that cross-talk between tumour cells and MSCs has been shown to increase metastatic potential and promote epithelial-to-mesenchymal transition. This review will focus on the role of MSCs in tumour development at various stages of progression from growth of the primary tumour to the establishment of distant metastasis.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 343 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 <1%
United States 1 <1%
Netherlands 1 <1%
Unknown 340 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 77 22%
Student > Bachelor 52 15%
Student > Master 52 15%
Researcher 35 10%
Student > Doctoral Student 19 6%
Other 46 13%
Unknown 62 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 100 29%
Agricultural and Biological Sciences 48 14%
Medicine and Dentistry 48 14%
Engineering 17 5%
Immunology and Microbiology 17 5%
Other 37 11%
Unknown 76 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2017.
All research outputs
#1,808,531
of 14,308,102 outputs
Outputs from Molecular Cancer
#68
of 1,221 outputs
Outputs of similar age
#59,494
of 349,569 outputs
Outputs of similar age from Molecular Cancer
#1
of 1 outputs
Altmetric has tracked 14,308,102 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,221 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,569 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them