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Mesenchymal stem cells: key players in cancer progression

Overview of attention for article published in Molecular Cancer, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
1 news outlet
twitter
13 X users
wikipedia
1 Wikipedia page

Citations

dimensions_citation
397 Dimensions

Readers on

mendeley
432 Mendeley
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Title
Mesenchymal stem cells: key players in cancer progression
Published in
Molecular Cancer, February 2017
DOI 10.1186/s12943-017-0597-8
Pubmed ID
Authors

Sarah M. Ridge, Francis J. Sullivan, Sharon A. Glynn

Abstract

Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, cells of the immune system and mesenchymal stem cells (MSCs). MSCs are multipotent stromal cells that are known to reside in various areas such as the bone marrow, fat and dental pulp. MSCs have been found to migrate towards inflammatory sites and studies have shown that they also migrate towards and incorporate into the tumour. The key question is how they interact there. MSCs may interact with tumour cells through paracrine signalling. On the other hand, MSCs have the capacity to differentiate to various cell types such as osteocytes, chondrocytes and adipocytes and it is possible that MSCs differentiate at the site of the tumour. More recently it has been shown that cross-talk between tumour cells and MSCs has been shown to increase metastatic potential and promote epithelial-to-mesenchymal transition. This review will focus on the role of MSCs in tumour development at various stages of progression from growth of the primary tumour to the establishment of distant metastasis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 432 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 <1%
Netherlands 1 <1%
United States 1 <1%
Unknown 429 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 83 19%
Student > Bachelor 60 14%
Student > Master 56 13%
Researcher 46 11%
Student > Doctoral Student 24 6%
Other 51 12%
Unknown 112 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 113 26%
Medicine and Dentistry 58 13%
Agricultural and Biological Sciences 51 12%
Engineering 21 5%
Immunology and Microbiology 16 4%
Other 48 11%
Unknown 125 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2022.
All research outputs
#1,649,590
of 25,250,629 outputs
Outputs from Molecular Cancer
#91
of 1,902 outputs
Outputs of similar age
#34,472
of 431,941 outputs
Outputs of similar age from Molecular Cancer
#2
of 43 outputs
Altmetric has tracked 25,250,629 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,902 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 431,941 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.