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An Arabidopsis SET domain protein required for maintenance but not establishment of DNA methylation

Overview of attention for article published in EMBO Journal, December 2002
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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Citations

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143 Mendeley
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Title
An Arabidopsis SET domain protein required for maintenance but not establishment of DNA methylation
Published in
EMBO Journal, December 2002
DOI 10.1093/emboj/cdf687
Pubmed ID
Authors

F. Malagnac

Abstract

Cytosine methylation is critical for correct development and genome stability in mammals and plants. In order to elucidate the factors that control genomic DNA methylation patterning, a genetic screen for mutations that disrupt methylation-correlated silencing of the endogenous gene PAI2 was conducted in Arabidopsis: This screen yielded seven loss-of-function alleles in a SET domain protein with histone H3 Lys9 methyltransferase activity, SUVH4. The mutations conferred reduced cytosine methylation on PAI2, especially in non-CG sequence contexts, but did not affect methylation on another PAI locus carrying two genes arranged as an inverted repeat. Moreover, an unmethylated PAI2 gene could be methylated de novo in the suvh4 mutant background. These results suggest that SUVH4 is involved in maintenance but not establishment of methylation at particular genomic regions. In contrast, a heterochromatin protein 1 homolog, LHP1, had no effect on PAI methylation.

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
United Kingdom 2 1%
Brazil 2 1%
Czechia 1 <1%
France 1 <1%
Singapore 1 <1%
Argentina 1 <1%
Germany 1 <1%
Unknown 132 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 34%
Researcher 40 28%
Student > Master 12 8%
Professor > Associate Professor 9 6%
Professor 9 6%
Other 18 13%
Unknown 7 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 103 72%
Biochemistry, Genetics and Molecular Biology 25 17%
Environmental Science 2 1%
Pharmacology, Toxicology and Pharmaceutical Science 2 1%
Medicine and Dentistry 2 1%
Other 3 2%
Unknown 6 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2017.
All research outputs
#2,990,723
of 12,024,798 outputs
Outputs from EMBO Journal
#2,961
of 9,322 outputs
Outputs of similar age
#2,892,806
of 11,376,893 outputs
Outputs of similar age from EMBO Journal
#2,895
of 9,138 outputs
Altmetric has tracked 12,024,798 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 9,322 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 11,376,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 9,138 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.