Chapter title |
Metabolomics: Definitions and Significance in Systems Biology
|
---|---|
Chapter number | 1 |
Book title |
Metabolomics: From Fundamentals to Clinical Applications
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-47656-8_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-947655-1, 978-3-31-947656-8
|
Authors |
Aline Klassen, Andréa Tedesco Faccio, Gisele André Baptista Canuto, Pedro Luis Rocha da Cruz, Henrique Caracho Ribeiro, Marina Franco Maggi Tavares, Alessandra Sussulini |
Editors |
Alessandra Sussulini |
Abstract |
Nowadays, there is a growing interest in deeply understanding biological mechanisms not only at the molecular level (biological components) but also the effects of an ongoing biological process in the organism as a whole (biological functionality), as established by the concept of systems biology. Within this context, metabolomics is one of the most powerful bioanalytical strategies that allow obtaining a picture of the metabolites of an organism in the course of a biological process, being considered as a phenotyping tool. Briefly, metabolomics approach consists in identifying and determining the set of metabolites (or specific metabolites) in biological samples (tissues, cells, fluids, or organisms) under normal conditions in comparison with altered states promoted by disease, drug treatment, dietary intervention, or environmental modulation. The aim of this chapter is to review the fundamentals and definitions used in the metabolomics field, as well as to emphasize its importance in systems biology and clinical studies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 161 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 16% |
Student > Master | 21 | 13% |
Student > Bachelor | 18 | 11% |
Student > Doctoral Student | 16 | 10% |
Researcher | 16 | 10% |
Other | 13 | 8% |
Unknown | 51 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 33 | 20% |
Biochemistry, Genetics and Molecular Biology | 21 | 13% |
Agricultural and Biological Sciences | 13 | 8% |
Medicine and Dentistry | 12 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 24 | 15% |
Unknown | 54 | 34% |