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Odorant receptors instruct functional circuitry in the mouse olfactory bulb

Overview of attention for article published in Nature, September 2002
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Title
Odorant receptors instruct functional circuitry in the mouse olfactory bulb
Published in
Nature, September 2002
DOI 10.1038/nature01001
Pubmed ID
Authors

Leonardo Belluscio, Claudia Lodovichi, Paul Feinstein, Peter Mombaerts, Lawrence C. Katz

Abstract

The mammalian olfactory system detects and discriminates thousands of odorants using many different receptors expressed by sensory neurons in the nasal epithelium. Axonal projections from these neurons to the main olfactory bulbs form reproducible patterns of glomeruli in two widely separated regions of each bulb, creating two mirror-symmetric maps of odorant receptor projections. To investigate whether odorant receptors organize neural circuitry in the olfactory bulb, we have examined a genetically modified mouse line, rI7 --> M71, in which a functionally characterized receptor, rI7, has been substituted into the M71 receptor locus. Here we show that despite their ectopic location the resulting glomeruli are responsive to known ligands of the rI7 receptor, attract postsynaptic innervation by mitral/tufted cell dendrites, and endow these cells with responses that are characteristic of the rI7 receptor. External tufted cells receiving input from rI7 --> M71 glomeruli form precise intrabulbar projections that link medial and lateral rI7 --> M71 glomeruli anatomically, thus providing a substrate for coordinating isofunctional glomeruli. We conclude that odorant receptor identity in epithelial neurons determines not only glomerular convergence and function, but also functional circuitry in the olfactory bulb.

Mendeley readers

The data shown below were compiled from readership statistics for 172 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 7 4%
United States 4 2%
Portugal 2 1%
France 2 1%
Greece 2 1%
Japan 2 1%
Denmark 1 <1%
United Kingdom 1 <1%
Unknown 151 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 52 30%
Student > Ph. D. Student 49 28%
Professor 19 11%
Professor > Associate Professor 14 8%
Student > Master 10 6%
Other 19 11%
Unknown 9 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 103 60%
Neuroscience 25 15%
Medicine and Dentistry 9 5%
Biochemistry, Genetics and Molecular Biology 6 3%
Engineering 3 2%
Other 13 8%
Unknown 13 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2002.
All research outputs
#2,015,221
of 3,633,425 outputs
Outputs from Nature
#29,469
of 34,753 outputs
Outputs of similar age
#1,475,531
of 2,729,819 outputs
Outputs of similar age from Nature
#28,400
of 33,613 outputs
Altmetric has tracked 3,633,425 research outputs across all sources so far. This one is in the 26th percentile – i.e., 26% of other outputs scored the same or lower than it.
So far Altmetric has tracked 34,753 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.3. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 2,729,819 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33,613 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.