Title |
Biological mechanisms of gold nanoparticle radiosensitization
|
---|---|
Published in |
Cancer Nanotechnology, February 2017
|
DOI | 10.1186/s12645-017-0026-0 |
Pubmed ID | |
Authors |
Soraia Rosa, Chris Connolly, Giuseppe Schettino, Karl T. Butterworth, Kevin M. Prise |
Abstract |
There has been growing interest in the use of nanomaterials for a range of biomedical applications over the last number of years. In particular, gold nanoparticles (GNPs) possess a number of unique properties that make them ideal candidates as radiosensitizers on the basis of their strong photoelectric absorption coefficient and ease of synthesis. However, despite promising preclinical evidence in vitro supported by a limited amount of in vivo experiments, along with advances in mechanistic understanding, GNPs have not yet translated into the clinic. This may be due to disparity between predicted levels of radiosensitization based on physical action, observed biological response and an incomplete mechanistic understanding, alongside current experimental limitations. This paper provides a review of the current state of the field, highlighting the potential underlying biological mechanisms in GNP radiosensitization and examining the barriers to clinical translation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 22% |
United States | 1 | 11% |
Unknown | 6 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 56% |
Science communicators (journalists, bloggers, editors) | 2 | 22% |
Scientists | 1 | 11% |
Unknown | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Poland | 1 | <1% |
Unknown | 252 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 65 | 26% |
Student > Master | 41 | 16% |
Researcher | 32 | 13% |
Student > Bachelor | 31 | 12% |
Student > Doctoral Student | 10 | 4% |
Other | 35 | 14% |
Unknown | 40 | 16% |
Readers by discipline | Count | As % |
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Physics and Astronomy | 45 | 18% |
Biochemistry, Genetics and Molecular Biology | 28 | 11% |
Medicine and Dentistry | 26 | 10% |
Chemistry | 23 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 17 | 7% |
Other | 64 | 25% |
Unknown | 51 | 20% |