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Low back pain and FokI (rs2228570) polymorphism of vitamin D receptor in athletes

Overview of attention for article published in BMC Sports Science, Medicine and Rehabilitation, February 2017
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Title
Low back pain and FokI (rs2228570) polymorphism of vitamin D receptor in athletes
Published in
BMC Sports Science, Medicine and Rehabilitation, February 2017
DOI 10.1186/s13102-017-0069-x
Pubmed ID
Authors

Sabina Cauci, Francesca Migliozzi, Carlo Simone Trombetta, Ilaria Venuto, Paola Saccheri, Luciana Travan, Giovanni Chiriacò

Abstract

Low back pain (LBP) is common in athletes. LBP can be detrimental to athletic performance and health. Factors predisposing to LBP in athletes remain elusive and require further studies. We investigated whether carriage of a specific genotype and/or allele of vitamin D receptor gene (VDR) FokI polymorphism (rs2228570) was a risk factor for LBP in athletes of different sports disciplines. This genotype/phenotype association case-control study included 60 Italian athletes (25 females and 35 males; mean age 33.9 ± 13.3 years; body-mass-index 23.5 ± 3.5 kg/m(2)) of which 16.7% were swimmers, 11.7% soccer players, 11.7% volleyball players, 10.0% rugby players and other disciplines. VDR-FokI polymorphism was measured by PCR-RFLP in 24 athletes with LBP and 36 athletes without LBP episodes. Absence or presence of the FokI restriction site was denoted "F" and "f", respectively. Other risk factors were evaluated by a questionnaire. The homozygous FF genotype was found in 58.3% (14/24) of athletes with LBP versus 27.8% (10/36) of athletes without LBP, adjusted OR = 5.78, 95% CI 1.41-23.8, P = 0.015. The F allele was a 2-fold risk factor to develop LBP, adjusted OR = 2.55, 95% CI 1.02-6.43, P = 0.046, while f allele was protective. Exposure to vehicle vibrations ≥2 h daily, and family history of lumbar spine pathology were significant risk factors for LBP with OR = 3.54, and OR = 9.21, respectively. This is the first study in which an association between VDR-FokI polymorphism and LBP in athletes was found. Further research is needed to extend our results, and to clarify the biochemical pathways associated with how vitamin D modulates LBP in athletes. The VDR-FokI polymorphism should be considered when developing genetic focused studies of precision medicine on health in athletes.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 26%
Student > Bachelor 5 12%
Researcher 5 12%
Student > Ph. D. Student 5 12%
Lecturer 3 7%
Other 7 16%
Unknown 7 16%
Readers by discipline Count As %
Medicine and Dentistry 11 26%
Biochemistry, Genetics and Molecular Biology 6 14%
Nursing and Health Professions 5 12%
Neuroscience 3 7%
Sports and Recreations 3 7%
Other 5 12%
Unknown 10 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 April 2019.
All research outputs
#8,483,827
of 14,656,415 outputs
Outputs from BMC Sports Science, Medicine and Rehabilitation
#146
of 213 outputs
Outputs of similar age
#168,202
of 350,284 outputs
Outputs of similar age from BMC Sports Science, Medicine and Rehabilitation
#3
of 3 outputs
Altmetric has tracked 14,656,415 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 213 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.5. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 350,284 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.