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DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

Overview of attention for article published in Nature Immunology, August 2002
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

blogs
2 blogs
patent
4 patents
peer_reviews
1 peer review site
f1000
1 research highlight platform

Citations

dimensions_citation
920 Dimensions

Readers on

mendeley
204 Mendeley
citeulike
1 CiteULike
connotea
1 Connotea
Title
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Published in
Nature Immunology, August 2002
DOI 10.1038/ni829
Pubmed ID
Authors

Mikhail B. Litinskiy, Bernardetta Nardelli, David M. Hilbert, Bing He, Andras Schaffer, Paolo Casali, Andrea Cerutti

Abstract

Immunoglobulin (Ig) class-switch DNA recombination (CSR) is thought to be highly dependent upon engagement of CD40 on B cells by CD40 ligand on T cells. We show here that dendritic cells up-regulate BLyS and APRIL upon exposure to interferon-alpha, interferon-gamma or CD40 ligand. In the presence of interleukin 10 (IL-10) or transforming growth factor-beta, BLyS and APRIL induce CSR from C(mu) to C(gamma) and/or C(alpha) genes in B cells, whereas CSR to C(epsilon) requires IL-4. Secretion of class-switched antibodies requires additional stimulation by B cell antigen receptor engagement and IL-15. By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses.

Mendeley readers

The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 <1%
United States 2 <1%
Denmark 1 <1%
Brazil 1 <1%
Japan 1 <1%
Switzerland 1 <1%
Hungary 1 <1%
India 1 <1%
Unknown 194 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 58 28%
Researcher 54 26%
Student > Master 23 11%
Student > Bachelor 13 6%
Professor 11 5%
Other 45 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 82 40%
Medicine and Dentistry 49 24%
Immunology and Microbiology 34 17%
Biochemistry, Genetics and Molecular Biology 14 7%
Unspecified 13 6%
Other 12 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2019.
All research outputs
#928,325
of 12,913,752 outputs
Outputs from Nature Immunology
#465
of 2,830 outputs
Outputs of similar age
#900,562
of 12,333,169 outputs
Outputs of similar age from Nature Immunology
#463
of 2,826 outputs
Altmetric has tracked 12,913,752 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,830 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 12,333,169 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 2,826 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.